AIMC Topic: Antirheumatic Agents

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The Economic Burden of ACPA-Positive Status Among Patients with Rheumatoid Arthritis.

Journal of managed care & specialty pharmacy
BACKGROUND: Anticitrullinated protein antibodies (ACPAs) are serological biomarkers associated with early, rapidly progressing rheumatoid arthritis (RA), including more severe disease and joint damage. ACPA testing has become a routine tool for RA di...

The use of natural language processing on narrative medication schedules to compute average weekly dose.

Pharmacoepidemiology and drug safety
PURPOSE: Medications with non-standard dosing and unstandardized units of measurement make the estimation of prescribed dose difficult from pharmacy dispensing data. A natural language processing tool named the SIG extractor was developed to identify...

Defining Disease Phenotypes in Primary Care Electronic Health Records by a Machine Learning Approach: A Case Study in Identifying Rheumatoid Arthritis.

PloS one
OBJECTIVES: 1) To use data-driven method to examine clinical codes (risk factors) of a medical condition in primary care electronic health records (EHRs) that can accurately predict a diagnosis of the condition in secondary care EHRs. 2) To develop a...

Advances in pharmacotherapy of juvenile idiopathic arthritis.

Expert opinion on pharmacotherapy
INTRODUCTION: Juvenile Idiopathic Arthritis (JIA) is the most common chronic rheumatic disease in childhood. More therapeutic options are available for the treatment of JIA with more children achieving minimal active disease or inactive disease statu...

Prediction of Anti-rheumatoid Arthritis Natural Products of Xanthocerais Lignum Based on LC-MS and Artificial Intelligence.

Combinatorial chemistry & high throughput screening
AIMS: Employing the technique of liquid chromatography-mass spectrometry (LCMS) in conjunction with artificial intelligence (AI) technology to predict and screen for antirheumatoid arthritis (RA) active compounds in Xanthocerais lignum.

Alkaloids, flavonoids, polyphenols might be responsible for potent antiarthritic effect of Solanum nigrum.

Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan
OBJECTIVE: To evaluate in vitro and in vivo antiarthritic potential of Solanum nigrum (S. nigrum).