AIMC Topic: Arthritis, Rheumatoid

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Identification of potential pathogenic genes associated with the comorbidity of rheumatoid arthritis and renal fibrosis using bioinformatics and machine learning.

Scientific reports
This study aimed to identify the potential pathogenic genes associated with the comorbidity of rheumatoid arthritis (RA) and renal fibrosis (RF). Transcriptomic data related to RA and RF were retrieved from the GEO database. Differential expression g...

Shared gene signatures and molecular mechanisms link ankylosing spondylitis and rheumatoid arthritis.

Scientific reports
Ankylosing spondylitis (AS) and rheumatoid arthritis (RA) are closely related autoimmune diseases with shared mechanisms that remain unclear. This study aims to identify shared molecular signatures and hub genes underlying the co-occurrence of AS and...

Transcriptomic insights into the mechanism of action of telomere-related biomarkers in rheumatoid arthritis.

Frontiers in immunology
BACKGROUND: Rheumatoid arthritis (RA) is an autoimmune inflammatory disease. The mechanism by which telomeres are involved in the development of RA remains unclear. This study aimed to investigate the relationship between RA and telomeres.

RNAcare: integrating clinical data with transcriptomic evidence using rheumatoid arthritis as a case study.

BMC medical genomics
BACKGROUND: Gene expression analysis is a crucial tool for uncovering the biological mechanisms that underlie differences between patient subgroups, offering insights that can inform clinical decisions. However, despite its potential, gene expression...

The Role of Artificial Intelligence in the Diagnosis and Management of Rheumatoid Arthritis.

Medicina (Kaunas, Lithuania)
Artificial intelligence has emerged as a transformative tool in healthcare, offering capabilities such as early diagnosis, personalised treatment, and real-time patient monitoring. In the context of rheumatoid arthritis, a chronic autoimmune disease...

Diagnostic performance of attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopy for detecting osteoarthritis and rheumatoid arthritis from blood serum.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
Osteoarthritis (OA) and rheumatoid arthritis (RA) are the two most common rheumatic diseases worldwide, causing pain and disability. Both conditions are highly heterogeneous, and their onset occurs insidiously with non-specific symptoms, so they are ...

Artificial intelligence to predict treatment response in rheumatoid arthritis and spondyloarthritis: a scoping review.

Rheumatology international
To analyse the types and applications of artificial intelligence (AI) technologies to predict treatment response in rheumatoid arthritis (RA) and spondyloarthritis (SpA). A comprehensive search in Medline, Embase, and Cochrane databases (up to August...

Common genetic variants do not impact clinical prediction of methotrexate treatment outcomes in early rheumatoid arthritis.

Journal of internal medicine
BACKGROUND: Methotrexate (MTX) is the mainstay initial treatment of rheumatoid arthritis (RA), but individual response varies and remains difficult to predict. The role of genetics remains unclear, but studies suggest its importance.

Intelligent Bi-Dimensional Skin Biopsies of Rheumatoid Arthritis Based on Raman Spectral Imaging and Machine Learning.

Analytical chemistry
Rheumatoid arthritis (RA) is one of the most common autoimmune diseases worldwide, characterized by its progressive and irreversible nature. Early diagnosis is crucial for delaying disease progression and optimizing treatment strategies. Existing dia...

Predicting rheumatoid arthritis progression from seronegative undifferentiated arthritis using machine learning: a deep learning model trained on the KURAMA cohort and externally validated with the ANSWER cohort.

Arthritis research & therapy
BACKGROUND: Undifferentiated arthritis (UA) often develops into rheumatoid arthritis (RA), but predicting disease progression from seronegative UA remains challenging because seronegative RA often does not meet the classification criteria. This study...