AIMC Topic: beta-Lactamases
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Evolutionary insights into the active-site structures of the metallo-β-lactamase superfamily from a classification study with support vector machine.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry
Sep 18, 2020
The metallo-β-lactamase (MβL) superfamily, which is intriguing due to its enzyme promiscuity, is a good model enzyme superfamily for studies of catalytic function evolution. Our previous study traced the evolution of the phosphotriesterase activity o...
Applications of machine-learning methods for the discovery of NDM-1 inhibitors.
Chemical biology & drug design
Jun 20, 2020
The emergence of New Delhi metal beta-lactamase (NDM-1)-producing bacteria and their worldwide spread pose great challenges for the treatment of drug-resistant bacterial infections. These bacteria can hydrolyze most β-lactam antibacterials. Unfortuna...
Molecular mechanisms of antibiotic co-resistance among carbapenem resistant Acinetobacter baumannii.
Journal of infection in developing countries
Oct 31, 2019
INTRODUCTION: The spread of carbapenem-resistant Acinetobacter baumannii (CRAB) is difficult to control especially in the hospitals due to the successful mobilization and evolution of the genetic elements harboring the resistant determinants. The stu...
Estimating the association between antibiotic exposure and colonization with extended-spectrum β-lactamase-producing Gram-negative bacteria using machine learning methods: a multicentre, prospective cohort study.
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
May 23, 2019
OBJECTIVES: The aim of the study was to measure the impact of antibiotic exposure on the acquisition of colonization with extended-spectrum β-lactamase-producing Gram-negative bacteria (ESBL-GNB) accounting for individual- and group-level confounding...
Detection of Extended-Spectrum β-Lactamase-Producing Escherichia coli Using Infrared Microscopy and Machine-Learning Algorithms.
Analytical chemistry
Jan 25, 2019
The spread of multidrug resistant bacteria has become a global concern. One of the most important and emergent classes of multidrug-resistant bacteria is extended-spectrum β-lactamase-producing bacteria (ESBL-positive = ESBL). Due to widespread and c...
In vitro activity of flomoxef against extended-spectrum β-lactamase-producing Escherichia coli and Klebsiella pneumoniae in Korea.
Diagnostic microbiology and infectious disease
Nov 26, 2018
To find an alternative regimen for the treatment of extended-spectrum β-lactamase (EBSL)-producing Enterobacteriaceae infections, we examined the in vitro activity of flomoxef against Escherichia coli and Klebsiella pneumoniae having CTX-M-1 group an...
BlaPred: Predicting and classifying β-lactamase using a 3-tier prediction system via Chou's general PseAAC.
Journal of theoretical biology
Aug 20, 2018
Antibiotics of β-lactam class account for nearly half of the global antibiotic use. The β-lactamase enzyme is a major element of the bacterial arsenals to escape the lethal effect of β-lactam antibiotics. Different variants of β-lactamases have evolv...
Baicalin inhibits Escherichia coli isolates in bovine mastitic milk and reduces antimicrobial resistance.
Journal of dairy science
Dec 28, 2017
In this study, we aimed to evaluate the inhibitory effect of baicalin on Escherichia coli in vitro and the effects of baicalin treatment on antimicrobial resistance of the E. coli isolates. Through isolation, purification, and identification, a total...
CNN-BLPred: a Convolutional neural network based predictor for β-Lactamases (BL) and their classes.
BMC bioinformatics
Dec 28, 2017
BACKGROUND: The β-Lactamase (BL) enzyme family is an important class of enzymes that plays a key role in bacterial resistance to antibiotics. As the newly identified number of BL enzymes is increasing daily, it is imperative to develop a computationa...
Occurrence and characteristics of extended-spectrum β-lactamase- and carbapenemase- producing bacteria from hospital effluents in Singapore.
The Science of the total environment
Oct 17, 2017
One of the most important resistance mechanisms in Gram-negative bacteria today is the production of enzymes causing resistance to cephalosporin and carbapenem antibiotics. The spread of extended-spectrum β-lactamases (ESBL)- and carbapenemase- produ...
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