Cellular heterogeneity of epithelial cells and fibroblasts is critical in esophageal squamous cell carcinoma development (ESCC). Identifying dysregulated subtype-specific genes in these cells is essential for early diagnosis and treatment. In this st...
Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society
Aug 11, 2025
Tumor mutation burden (TMB) is a crucial biomarker for predicting the response of lung cancer patients to immunotherapy. Traditionally, TMB is quantified through whole-exome sequencing (WES), but the high costs and time requirements of WES limit its ...
BACKGROUND: Acute Myeloid Leukemia (AML) is a highly heterogeneous hematologic malignancy influenced by various factors affecting prognosis. Recently, the role of coagulation-related genes in tumor biology has garnered increasing attention. This stud...
BACKGROUND: Tumor biomarkers have been implicated in heart failure (HF). This study aimed to explore the role of tumor biomarkers in the occurrence and progression of HF.
This study aimed to investigate the potential of peptide mass fingerprints (PMFs) of the serum peptidome using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS), in combination with machine learning algorithm...
Pancreatic cancer (PC) is a highly aggressive malignancy in humans, where early diagnosis significantly improves patient outcomes. However, effective methods for accurate and early detection remain limited. In this multiethnic study involving human s...
Head and Neck Squamous Cell Carcinoma (HNSCC) is the seventh most prevalent cancer worldwide and is classified as human papillomavirus (HPV) positive or negative. Substantial heterogeneity has been observed in the two groups, posing a significant cli...
The mortality rates have been increasing for glioma in adolescents and young adults (AYAs, aged 15-39 years). However, current biomarkers for clinical assessment in AYAs glioma are limited, prompting the urgent need for identifying ideal prognostic s...
Immuno-oncology and the advent of immunotherapies, in particular immune checkpoint inhibitors (ICIs), have fundamentally altered the way we treat cancer. Yet only a small subset of patients actually responds to ICIs, and many face significant adverse...
Papillary thyroid carcinoma (PTC) is the main pathological subtype of thyroid cancer. Given the strong association between T cells and PTC, this study focused on the prognostic value and potential molecular mechanisms of T cell proliferation-related ...
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