AIMC Topic: Biomarkers

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Biomarker genes for model-based prediction of drought-stress perception levels in rice.

BMC plant biology
BACKGROUND: Drought is a global challenge that severely restricts crop yields and threatens food security. Plants respond to drought stress by modulating gene expression before visible phenotypic changes occur. However, most studies of drought resist...

The long-term neuroprotective effect of MIND and Mediterranean diet on patients with Alzheimer's disease.

Scientific reports
Alzheimer's disease is a progressive neurodegenerative disorder with no cure, making preventive strategies crucial. Dietary interventions, particularly the Mediterranean (MeDi) and MIND diets, have been associated with reduced cognitive decline, but ...

Machine learning comparison for biomarker level estimation in wastewater dynamics monitoring.

Scientific reports
Wastewater surveillance is an emerging strategy that enables monitoring of the presence and dynamic changes of targeted substances, facilitating improved allocation of preventive actions and public health interventions. This paper investigates the ap...

Machine learning and data-driven inverse modeling of metabolomics unveil key processes of active aging.

NPJ systems biology and applications
Physical inactivity and low fitness have become global health concerns. Metabolomics, as an integrative approach, may link fitness to molecular changes. In this study, we analyzed blood metabolomes from elderly individuals under different treatments....

Micro- and nanoscale biosensing technologies for early diagnosis of Parkinson's disease.

Mikrochimica acta
Parkinson's disease (PD), the second most prevalent neurodegenerative disorder, remains challenging to diagnose at its earliest stages due to the absence of definitive biomarkers and overlapping clinical features with other synucleinopathies, thereby...

Prediction of biological age using machine learning.

PloS one
In response to Taiwan's rapidly aging population and the rising demand for personalized health care, accurately assessing individual physiological aging has become an essential area of study. This research utilizes health examination data to propose ...

Biomechanical and physiological biomarkers are useful indicators of military personnel readiness: a multi-institutional, multinational research collaboration.

BMJ military health
A ubiquitous problem facing military organisations is musculoskeletal injury (MSKI) risk identification. Recently, two research groups, each with their own funding, collaborated to address this problem. Combining their respective areas of expertise i...

Risk prediction of all-cause mortality in hospitalized patients with severe acute pancreatitis by serum urea nitrogen/albumin ratio.

PloS one
BACKGROUND: Classification of risk levels in patients with acute pancreatitis remains a difficult task. Although some biomarkers have emerged to predict the prognosis of patients with acute pancreatitis, they have not been widely used in clinical pra...

Revealing and validating the biomarkers associated with demethylation in major depressive disorder: comprehensive insights based on bulk RNA sequencing data, single-nucleus RNA sequencing data, and clinical experiments.

Journal of affective disorders
BACKGROUND: The demethylation is suspected to play a role in the development of major depressive disorder (MDD), but the precise biological mechanisms remain unclear. Therefore, this study aimed to investigate biomarkers linked to demethylation in MD...