AIMC Topic: Biopsy

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The emerging role of second harmonic generation/two photon excitation for precision digital analysis of liver fibrosis in MASH clinical trials.

Journal of hepatology
Conventional histopathological evaluation of liver biopsy slides has been invaluable in assessing the causes of liver injury, the severity of the underlying disease processes, and the degree of resulting fibrosis. However, the use of conventional his...

Assessing the diagnostic accuracy of ChatGPT-4 in the histopathological evaluation of liver fibrosis in MASH.

Hepatology communications
BACKGROUND: Large language models like ChatGPT have demonstrated potential in medical image interpretation, but their efficacy in liver histopathological analysis remains largely unexplored. This study aims to assess ChatGPT-4-vision's diagnostic acc...

Effective reduction of unnecessary biopsies through a deep-learning-assisted aggressive prostate cancer detector.

Scientific reports
Despite being one of the most prevalent cancers, prostate cancer (PCa) shows a significantly high survival rate, provided there is timely detection and treatment. Currently, several screening and diagnostic tests are required to be carried out in ord...

Diagnostic Adjuncts and Biopsy Techniques for Oral Potentially Malignant Disorders and Oral Cavity Squamous Cell Carcinoma.

Dental clinics of North America
Diagnostic adjuncts for oral potentially malignant disorders such as leukoplakia or erythroplakia can aid the clinician in triaging abnormal lesions and facilitate both biopsy site selection and surgical management. No adjuncts replace gold standard ...

Pancreas rejection: quieting the storm to preserve graft function.

Current opinion in organ transplantation
PURPOSE OF REVIEW: Allograft rejection remains enigmatic and elusive following pancreas transplantation. In the absence of early technical pancreas graft failure, pancreas allograft rejection is the major cause of death-censored pancreas graft loss b...

Rapid diagnosis of membranous nephropathy based on kidney tissue Raman spectroscopy and deep learning.

Scientific reports
Membranous nephropathy (MN) is one of the most common glomerular diseases. Although the diagnostic method based on serum PLA2R antibodies has gradually been applied in clinical practice, only 52-86% of PLA2R-associated MN patients show positive anti-...

Neural network analysis as a novel skin outcome in a trial of belumosudil in patients with systemic sclerosis.

Arthritis research & therapy
BACKGROUND: The modified Rodnan skin score (mRSS), a measure of systemic sclerosis (SSc) skin thickness, is agnostic to inflammation and vasculopathy. Previously, we demonstrated the potential of neural network-based digital pathology applied to SSc ...

Intelligent Bi-Dimensional Skin Biopsies of Rheumatoid Arthritis Based on Raman Spectral Imaging and Machine Learning.

Analytical chemistry
Rheumatoid arthritis (RA) is one of the most common autoimmune diseases worldwide, characterized by its progressive and irreversible nature. Early diagnosis is crucial for delaying disease progression and optimizing treatment strategies. Existing dia...

A first explainable-AI-based workflow integrating forward-forward and backpropagation-trained networks of label-free multiphoton microscopy images to assess human biopsies of rare neuromuscular disease.

Computer methods and programs in biomedicine
BACKGROUND AND OBJECTIVE: Diagnosis of rare neuromuscular diseases often relies on muscle biopsy analysis, which varies based on the evaluator's experience. Advances in deep learning show promise in improving diagnostic accuracy by identifying standa...