BACKGROUND: Ultra-early detection of brain injury biomarkers within the critical first hour post-injury remains a major clinical challenge in mild traumatic brain injury (mTBI) management. Conventional platforms (e.g., ELISA) suffer from limited sens...
Degenerative joint diseases are major contributors to pain, impaired mobility, and an increasing socioeconomic burden in aging populations. Tissue Engineering (TE) offers alternative solutions to restore joint functions. However, current TE approache...
We report a proof-of-concept diagnostic strategy that integrates multiplexed Raman-tagged antibody labeling with label-free surface-enhanced Raman spectroscopy (SERS) and machine learning (ML) to improve the detection of ovarian cancer via extracellu...
Pancreatic cancer remains one of the deadliest malignancies due to its silent progression and lack of early diagnostic tools. Here, we report a light-addressable photoelectrochemical (LAMT-PEC) biosensing system featuring single-atom Au-TiO photoelec...
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
Jul 14, 2025
Over recent years, surface-enhanced Raman spectroscopy (SERS) has shown its unparalleled sensitivity and molecular specificity in biomedical applications. However, noninvasive and sensitive detection of biomarkers with conventional SERS for oral canc...
Population aging presents significant health challenges and socioeconomic burdens globally, driving an increased demand for precision health management. In the era of big data, the exponential growth of health information is accelerating advances in ...
World journal of microbiology & biotechnology
Jul 12, 2025
Glucose oxidase (GOD), an oxidoreductase (EC 1.1.3.4), catalyzes the oxidation of β-D-glucose to gluconic acid using molecular oxygen as the electron acceptor, with concomitant generation of hydrogen peroxide. Owing to its versatile catalytic propert...
Breast cancer is the second leading cause of female mortality globally. Effective diagnostic tools, such as biosensors that utilize reliable biomarkers, are essential for early detection, particularly in low-income countries. This study introduces a ...
Lung cancer remains the leading cause of cancer-related mortality worldwide, largely due to late-stage diagnosis. Early detection is critical for improving patient outcomes, yet current screening methods, such as low-dose computed tomography (CT), of...
Journal of agricultural and food chemistry
Jul 9, 2025
Non-nucleic acid targets (non-NATs), such as heavy metals, toxins, and pesticide residues, pose critical threats to food safety. Although CRISPR/Cas systems were initially developed for nucleic acid detection, recent advances have enabled their adapt...
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