UNLABELLED: Bone metastasis (BM) is a leading cause of morbidity and mortality in patients with prostate and renal cancer. The complex and dynamic biological processes driving its progression present significant challenges for both understanding and ...
Osteosarcoma (OS) calls for early diagnosis to significantly improve patient survival rates. Exosomes hold significant potential as noninvasive biomarkers for the early diagnosis of cancer. Here, we design a microfluidic device to purify and analyze ...
Journal of the American Society for Mass Spectrometry
Sep 3, 2025
Lung cancer metastasis, the leading cause of patient mortality, is driven by circulating tumor cells (CTCs), which act as direct mediators of metastatic spread. To elucidate the metabolic heterogeneity across lung cancer metastatic stages, a panorami...
Ecotoxicology and environmental safety
Sep 1, 2025
BACKGROUND: Polycyclic aromatic hydrocarbons (PAHs), widely emitted through industrial processes and vehicular exhaust, are recognized environmental carcinogens. Although PAH exposure has been linked to various malignancies, the specific molecular me...
RATIONALE AND OBJECTIVES: A common site of metastases for a variety of cancers is the bone, which is challenging and time consuming to review and important for cancer staging. Here, we developed a deep learning approach for detection and classificati...
RATIONALE AND OBJECTIVES: This study aims to develop and validate a novel two-step deep learning framework for the automated detection, segmentation, and classification of bone metastases in SPECT/CT imaging, accurately distinguishing malignant from ...
RATIONALE AND OBJECTIVES: To explore the value of machine learning models based on MRI radiomics and automated habitat analysis in predicting bone metastasis and high-grade pathological Gleason scores in prostate cancer.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Jul 15, 2025
Osteosarcoma (OS) is an aggressive bone cancer that mainly occurs in children and adolescents. OS patients are mainly treated with neoadjuvant chemotherapy and surgical resection. This treatment is effective for early osteosarcoma. However, the effec...
Cancer is a deadly disease that occurs due to the uncontrolled growth of abnormal cells. Bone cancer is the third most occurring disease; approximately 10,000 patients suffer from bone cancer in India annually. It can lead to death if not diagnosed i...
BACKGROUND AND AIMS: Osteosarcoma (OS) is the most common primary bone malignancy, and neoadjuvant chemotherapy (NAC) improves survival rates. However, OS heterogeneity results in variable treatment responses, highlighting the need for reliable, non-...
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