AIMC Topic: Carcinoma, Non-Small-Cell Lung

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Identification of exosome-related genes in NSCLC via integrated bioinformatics and machine learning analysis.

Scientific reports Jul 2, 2025
Exosomes are crucial in the development of non-small cell lung cancer (NSCLC), yet exosome-associated genes in NSCLC remain insufficiently explored. The present study identified 59 exosome-associated differentially expressed genes (EA-DEGs) from the ...
Machine Learning Prognosis Biomarkers, Tumor Gene Expression Profiling Humans Gene Expression Regulation, Neoplastic Carcinoma, Non-Small-Cell Lung Databases, Genetic Exosomes Gene Regulatory Networks Lung Neoplasms Computational Biology
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Advances in molecular pathology and therapy of non-small cell lung cancer.

Signal transduction and targeted therapy Jun 15, 2025
Over the past two decades, non-small cell lung cancer (NSCLC) has witnessed encouraging advancements in basic and clinical research. However, substantial unmet needs remain for patients worldwide, as drug resistance persists as an inevitable reality....
Drug Resistance, Neoplasm Molecular Targeted Therapy Immunotherapy Carcinoma, Non-Small-Cell Lung Humans Lung Neoplasms
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Next-Generation Sequencing-Based Testing Among Patients With Advanced or Metastatic Nonsquamous Non-Small Cell Lung Cancer in the United States: Predictive Modeling Using Machine Learning Methods.

JMIR cancer Jun 11, 2025
BACKGROUND: Next-generation sequencing (NGS) has become a cornerstone of treatment for lung cancer and is recommended in current treatment guidelines for patients with advanced or metastatic disease.
Humans United States Male Female Carcinoma, Non-Small-Cell Lung Machine Learning Adult Aged Middle Aged Biomarkers, Tumor Lung Neoplasms High-Throughput Nucleotide Sequencing
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NeoPred: dual-phase CT AI forecasts pathologic response to neoadjuvant chemo-immunotherapy in NSCLC.

Journal for immunotherapy of cancer May 31, 2025
BACKGROUND: Accurate preoperative prediction of major pathological response or pathological complete response after neoadjuvant chemo-immunotherapy remains a critical unmet need in resectable non-small-cell lung cancer (NSCLC). Conventional size-base...
Humans Retrospective Studies Tomography, X-Ray Computed Female Treatment Outcome Middle Aged Neoadjuvant Therapy Aged Lung Neoplasms Adult Immunotherapy Male Carcinoma, Non-Small-Cell Lung
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Prediction of Lymph Node Metastasis in Non-Small Cell Lung Carcinoma Using Primary Tumor Somatic Mutation Data.

JCO clinical cancer informatics May 30, 2025
PURPOSE: Lymph node metastasis (LNM) significantly affects prognosis and treatment strategies in non-small cell lung cancer (NSCLC). Current diagnostic methods, including imaging and histopathology, have limited sensitivity and specificity. This stud...
Lung Neoplasms Polymorphism, Single Nucleotide Carcinoma, Non-Small-Cell Lung Male Middle Aged ROC Curve Lymphatic Metastasis Bayes Theorem Mutation Humans Machine Learning Aged Biomarkers, Tumor Prognosis Female
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Immunological biomarkers and gene signatures predictive of radiotherapy resistance in non-small cell lung cancer.

Frontiers in immunology May 29, 2025
INTRODUCTION: A significant challenge in treating non-small cell lung cancer (NSCLC) is its inherent resistance to radiation therapy, leading to poor patient prognosis. This study aimed to identify key genes influencing radiotherapy resistance in NSC...
Radiation Tolerance Gene Expression Regulation, Neoplastic Nomograms Carcinoma, Non-Small-Cell Lung Transcriptome Lung Neoplasms Computational Biology Biomarkers, Tumor Gene Expression Profiling Humans Prognosis
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Single-cell multimodal analysis reveals tumor microenvironment predictive of treatment response in non-small cell lung cancer.

Science advances May 23, 2025
Non-small cell lung cancer (NSCLC) constitutes over 80% of lung cancer cases and remains a leading cause of cancer-related mortality worldwide. Despite the advent of immune checkpoint inhibitors, their efficacy is limited to 27 to 45% of patients. Id...
Immunotherapy Single-Cell Analysis Humans Treatment Outcome Tumor Microenvironment Lung Neoplasms Carcinoma, Non-Small-Cell Lung Biomarkers, Tumor
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Non-invasive CT based multiregional radiomics for predicting pathologic complete response to preoperative neoadjuvant chemoimmunotherapy in non-small cell lung cancer.

European journal of radiology May 19, 2025
PURPOSE: This study aims to develop and validate a multiregional radiomics model to predict pathological complete response (pCR) to neoadjuvant chemoimmunotherapy in non-small cell lung cancer (NSCLC), and further evaluate the performance of the mode...
Radiomics Male Middle Aged Treatment Outcome Neoadjuvant Therapy Lung Neoplasms Immunotherapy Humans Reproducibility of Results Aged Adult Retrospective Studies Tomography, X-Ray Computed Female Carcinoma, Non-Small-Cell Lung Pathologic Complete Response
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Emerging research themes in ferroptosis research for non-small cell lung cancer: a bibliometric and visualized analysis.

Frontiers in immunology May 16, 2025
BACKGROUND: Ferroptosis, an iron-dependent form of regulated cell death, has garnered significant attention as a potential therapeutic target in oncology due to its unique mechanism involving lipid peroxidation and reactive oxygen species accumulatio...
Carcinoma, Non-Small-Cell Lung Bibliometrics Ferroptosis Humans Biomedical Research Lung Neoplasms
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Optimizing non small cell lung cancer detection with convolutional neural networks and differential augmentation.

Scientific reports May 5, 2025
Lung cancer remains one of the leading causes of cancer-related deaths worldwide, with early detection being critical to improving patient outcomes. Recent advancements in deep learning have shown promise in enhancing diagnostic accuracy, particularl...
Deep Learning Carcinoma, Non-Small-Cell Lung Humans Convolutional Neural Networks Neural Networks, Computer Lung Neoplasms Algorithms
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