AIMC Topic: Carrier Proteins

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Application of Feature Selection and Deep Learning for Cancer Prediction Using DNA Methylation Markers.

Genes Aug 29, 2022
DNA methylation is a process that can affect gene accessibility and therefore gene expression. In this study, a machine learning pipeline is proposed for the prediction of breast cancer and the identification of significant genes that contribute to t...
Humans Machine Learning Female Breast Neoplasms Carrier Proteins Genetic Markers Mitochondrial Proteins TATA-Binding Protein Associated Factors Deep Learning RNA-Binding Proteins Nuclear Proteins DNA Methylation
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Identification of efflux proteins based on contextual representations with deep bidirectional transformer encoders.

Analytical biochemistry Oct 14, 2021
Efflux proteins are the transport proteins expressed in the plasma membrane, which are involved in the movement of unwanted toxic substances through specific efflux pumps. Several studies based on computational approaches have been proposed to predic...
Support Vector Machine Carrier Proteins Natural Language Processing Computational Biology
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ActTRANS: Functional classification in active transport proteins based on transfer learning and contextual representations.

Computational biology and chemistry Jun 29, 2021
MOTIVATION: Primary and secondary active transport are two types of active transport that involve using energy to move the substances. Active transport mechanisms do use proteins to assist in transport and play essential roles to regulate the traffic...
Amino Acid Sequence Biological Transport, Active Support Vector Machine Carrier Proteins Natural Language Processing
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Application of the random forest algorithm to Streptococcus pyogenes response regulator allele variation: from machine learning to evolutionary models.

Scientific reports Jun 16, 2021
Group A Streptococcus (GAS) is a globally significant bacterial pathogen. The GAS genotyping gold standard characterises the nucleotide variation of emm, which encodes a surface-exposed protein that is recombinogenic and under immune-based selection ...
Humans Machine Learning Bacterial Proteins Antigens, Bacterial Streptococcus pyogenes Alleles Genome, Bacterial Genes, Bacterial Streptococcal Infections Regulon Bacterial Outer Membrane Proteins Genetic Variation Algorithms Carrier Proteins Evolution, Molecular
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Prediction of Protein-ATP Binding Residues Based on Ensemble of Deep Convolutional Neural Networks and LightGBM Algorithm.

International journal of molecular sciences Jan 19, 2021
Accurately identifying protein-ATP binding residues is important for protein function annotation and drug design. Previous studies have used classic machine-learning algorithms like support vector machine (SVM) and random forest to predict protein-AT...
Support Vector Machine Carrier Proteins Proteins Amino Acid Sequence Algorithms Protein Binding Computational Biology Adenosine Triphosphate Humans Neural Networks, Computer Machine Learning
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Identification of Methylated Gene Biomarkers in Patients with Alzheimer's Disease Based on Machine Learning.

BioMed research international Mar 26, 2020
BACKGROUND: Alzheimer's disease (AD) is a neurodegenerative disorder and characterized by the cognitive impairments. It is essential to identify potential gene biomarkers for AD pathology.
Humans Machine Learning Patients Peptide Hydrolases Carrier Proteins Cyclin-Dependent Kinase Inhibitor p57 Gene Expression Regulation, Neoplastic Mitochondrial Proteins DNA-Binding Proteins Protein Tyrosine Phosphatases Transcription Factors Microfilament Proteins Genetic Markers DNA Methylation Alzheimer Disease
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Computational Identification and Analysis of Ubiquinone-Binding Proteins.

Cells Feb 24, 2020
Ubiquinone is an important cofactor that plays vital and diverse roles in many biological processes. Ubiquinone-binding proteins (UBPs) are receptor proteins that dock with ubiquinones. Analyzing and identifying UBPs via a computational approach will...
Binding Sites Sequence Analysis, Protein Protein Interaction Domains and Motifs Position-Specific Scoring Matrices Carrier Proteins Amino Acid Sequence Ubiquinone Gene Ontology Protein Binding Computational Biology Membrane Proteins Humans Machine Learning
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Separation of HCM and LQT Cardiac Diseases with Machine Learning of Ca2+ Transient Profiles.

Methods of information in medicine Feb 20, 2020
BACKGROUND:  Modeling human cardiac diseases with induced pluripotent stem cells not only enables to study disease pathophysiology and develop therapies but also, as we have previously showed, it can offer a tool for disease diagnostics. We previousl...
Calcium Cardiomyopathy, Hypertrophic Carrier Proteins Humans Diagnosis, Differential Tropomyosin Machine Learning Signal Processing, Computer-Assisted Algorithms Long QT Syndrome
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A 21‑gene Support Vector Machine classifier and a 10‑gene risk score system constructed for patients with gastric cancer.

Molecular medicine reports Nov 21, 2019
Gastric cancer (GC) ranks fifth in terms of incidence and third in terms of tumor mortality worldwide. The present study was designed to construct a Support Vector Machine (SVM) classifier and risk score system for GC. The GSE62254 (training set) and...
Tumor Suppressor Proteins Kaplan-Meier Estimate Angiopoietin-like Proteins A Kinase Anchor Proteins Angiopoietin-Like Protein 1 Male Databases, Genetic Gene Expression Regulation, Neoplastic Middle Aged Carrier Proteins Membrane Proteins Gene Expression Profiling Humans Female Nerve Tissue Proteins Support Vector Machine Gene Regulatory Networks Cytokines Neoplasm Recurrence, Local Risk Factors Prognosis Aged Stomach Neoplasms
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Harnessing the evolutionary information on oxygen binding proteins through Support Vector Machines based modules.

BMC research notes May 11, 2018
OBJECTIVES: The arrival of free oxygen on the globe, aerobic life is becoming possible. However, it has become very clear that the oxygen binding proteins are widespread in the biosphere and are found in all groups of organisms, including prokaryotes...
Hemerythrin Animals Biological Evolution Support Vector Machine Hemeproteins Carrier Proteins Hemocyanins Oxygen
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