AIMC Topic: Cell Division

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Machine Learning of Hematopoietic Stem Cell Divisions from Paired Daughter Cell Expression Profiles Reveals Effects of Aging on Self-Renewal.

Cell systems Dec 8, 2020
Changes in stem cell activity may underpin aging. However, these changes are not completely understood. Here, we combined single-cell profiling with machine learning and in vivo functional studies to explore how hematopoietic stem cell (HSC) division...
Cell Division Hematopoietic Stem Cells Humans Machine Learning Aging Cell Differentiation
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CytoCensus, mapping cell identity and division in tissues and organs using machine learning.

eLife May 19, 2020
A major challenge in cell and developmental biology is the automated identification and quantitation of cells in complex multilayered tissues. We developed CytoCensus: an easily deployed implementation of supervised machine learning that extends conv...
Mutation Retina Zebrafish Time Factors Image Processing, Computer-Assisted Mice Drosophila melanogaster Cell Division Tissue Culture Techniques Embryo, Mammalian Animals, Genetically Modified Automation Brain Female Reproducibility of Results Animals Male Larva Machine Learning Phenotype Time-Lapse Imaging Microscopy, Video Organoids
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CTRL - a label-free artificial intelligence method for dynamic measurement of single-cell volume.

Journal of cell science Apr 14, 2020
Measuring the physical size of a cell is valuable in understanding cell growth control. Current single-cell volume measurement methods for mammalian cells are labor intensive, inflexible and can cause cell damage. We introduce CTRL: Cell Topography R...
Cell Size Animals Cell Division Artificial Intelligence Algorithms
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Chemical characterization, antioxidant, genotoxic and in vitro cytotoxic activity assessment of Juniperus communis var. saxatilis.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association Dec 26, 2017
Chemical composition and antioxidative, genotoxic and cytotoxic potential of essential oil (EO) and post-distillation waste (PDW) of Serbian Juniperus communis L. var. saxatilis Pall. was studied in human lung carcinoma (A549) and normal lung fibrobl...
Gas Chromatography-Mass Spectrometry Antioxidants Doxorubicin Animals Plant Extracts Apoptosis Mutagens Cell Division Male Rats Cell Line Humans G2 Phase Chromatography, Liquid Cell Line, Tumor Antineoplastic Agents, Phytogenic Female Juniperus Drug Screening Assays, Antitumor Tandem Mass Spectrometry
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Reconstructing cell cycle and disease progression using deep learning.

Nature communications Sep 6, 2017
We show that deep convolutional neural networks combined with nonlinear dimension reduction enable reconstructing biological processes based on raw image data. We demonstrate this by reconstructing the cell cycle of Jurkat cells and disease progressi...
Humans Jurkat Cells Diabetic Retinopathy Cell Cycle Neural Networks, Computer Machine Learning Disease Progression Cell Division Mitosis Computer Simulation DNA Reproducibility of Results Flow Cytometry
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Developmental time windows for axon growth influence neuronal network topology.

Biological cybernetics Jan 30, 2015
Early brain connectivity development consists of multiple stages: birth of neurons, their migration and the subsequent growth of axons and dendrites. Each stage occurs within a certain period of time depending on types of neurons and cortical layers....
Caenorhabditis elegans Neural Networks, Computer Neurogenesis Computer Simulation Time Synapses Animals Embryo, Nonmammalian Cell Division Models, Neurological Axons
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Deep learning-driven imaging of cell division and cell growth across an entire eukaryotic life cycle.

Molecular biology of the cell Jun 1, 2025
The life cycle of eukaryotic microorganisms involves complex transitions between states such as dormancy, mating, meiosis, and cell division, which are often studied independently from each other. Therefore, most microbial life cycles are theoretical...
Deep Learning Cell Proliferation Life Cycle Stages Algorithms Meiosis Saccharomyces cerevisiae Proteins CDC2 Protein Kinase Saccharomyces cerevisiae Cell Cycle Cell Division
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Interphase Cell Cycle Staging using Deep Learning.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference Jul 1, 2020
The progression of cells through the cell cycle is a tightly regulated process and is known to be key in maintaining normal tissue architecture and function. Disruption of these orchestrated phases will result in alterations that can lead to many dis...
Cell Division Interphase Deep Learning Cell Nucleus Cell Cycle
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