AIMC Topic: Cell Line, Tumor

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The cornucopia of meaningful leads: Applying deep adversarial autoencoders for new molecule development in oncology.

Oncotarget
Recent advances in deep learning and specifically in generative adversarial networks have demonstrated surprising results in generating new images and videos upon request even using natural language as input. In this paper we present the first applic...

Development of a Web-Enabled SVR-Based Machine Learning Platform and its Application on Modeling Transgene Expression Activity of Aminoglycoside-Derived Polycations.

Combinatorial chemistry & high throughput screening
OBJECTIVE: Support Vector Regression (SVR) has become increasingly popular in cheminformatics modeling. As a result, SVR-based machine learning algorithms, including Fuzzy-SVR and Least Square-SVR (LS-SVR) have been developed and applied in various r...

Redox-Responsive Amphipathic Dextran Nanomicelles for Solid Tumor Therapy.

Journal of biomedical nanotechnology
A disulfide bond containing deoxycholic acid-grafted dextran (Dex-SSDCA) was successfully prepared for drug delivery. The Dex-SSDCA polymers can self-assemble into nanomicelles at concentrations below 56 g/mL and encapsulate doxorubicin (DOX) effecti...

Computer aided prognosis for cell death categorization and prediction in vivo using quantitative ultrasound and machine learning techniques.

Medical physics
PURPOSE: At present, a one-size-fits-all approach is typically used for cancer therapy in patients. This is mainly because there is no current imaging-based clinical standard for the early assessment and monitoring of cancer treatment response. Here,...

The co-regulators SRC-1 and SMRT are involved in interleukin-6-induced androgen receptor activation.

European cytokine network
BACKGROUND: The androgen receptor (AR) can be stimulated by interleukin-6 (IL-6) in the absence of androgens to induce prostate cancer progression. The purpose of this study was to investigate whether the co-activator steroid receptor coactivator-1 (...

Diterpenoid Tanshinones, the extract from Danshen (Radix Salviae Miltiorrhizae) induced apoptosis in nine human cancer cell lines.

Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan
OBJECTIVE: To identify the active anti-tumor constituents in the extract from Danshen (Radix Salviae Miltiorrhizae) and investigate the mechanisms underlying the actions.

Learning approaches to improve prediction of drug sensitivity in breast cancer patients.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
Predicting drug response to cancer disease is an important problem in modern clinical oncology that attracted increasing recent attention from various domains such as computational biology, machine learning, and data mining. Cancer patients respond d...

Osteoinductive Activity of DFDBA Materials versus Growth Factors on Gene Expression of MG-63 Cells: An In Vitro Study.

Journal of long-term effects of medical implants
Guided bone regeneration using demineralized freeze-dried bone allograft (DFDBA) and growth factors (GFs) is a current goal in implant dentistry because of their potential osteoinductive abilities. Regarding controversial results, the purpose of this...

[Bovine lactoferrin decreases the invasion of Salmonella enterica to HEp-2 cells].

Revista de gastroenterologia del Peru : organo oficial de la Sociedad de Gastroenterologia del Peru
OBJECTIVE: To assess the effect of bovine lactoferrin (bLf) on the invasion of Salmonella enterica ser. Typhimurium to HEp-2 cells.