The study of stabilisation performance is a crucial consideration in the design of offshore floating platforms. For large floating structures, incorporating passive anti-roll tanks is a common technique for roll reduction. To investigate the feasibil...
This study aims to identify potential DYRK1A inhibitors from a curated database and utilize a QSAR model to predict the bioactivity of drug compounds in inhibiting the enzyme involved in tau protein oligomerization, a key process in AD pathology. 192...
Brains evolve within specific sensory and physical environments, yet neuroscience has traditionally focused on studying neural circuits in isolation. Understanding of their function requires integrative brain-body testing in realistic contexts. To in...
Achieving robust and energy-efficient navigation in unknown fluid environments remains a key challenge for bioinspired underwater robots. In this study, we develop a reinforcement learning-based control framework that enables a fish-like swimmer to a...
MALT1 is a key component of the CARD11-BCL10-MALT1 (CBM) complex downstream from BTK on the B-cell receptor signaling pathway. It is a key mediator of NF-κB signaling and considered a potential therapeutic target for several subtypes of non-Hodgkin's...
In silico drug-target interaction (DTI) prediction plays a key role in accelerating drug discovery and understanding molecular mechanisms. Traditional methods often struggle with the complexity and scale of biochemical data, thus limiting prediction ...
Recent developments in the theory of fuzzy graphs have led to many extensions for modeling real-world problems involving uncertainty. Among these, competition graphs are crucial for representing competitive and ecological systems. In this study, the ...
Recent neuroscience discoveries on human hand synergies have inspired the development of underactuated robotic hands, which replicate human-like grasping capabilities using a minimal number of actuators. However, a generalized methodology for determi...
The passive compliance of a soft worm-like body can be a key advantage for traversal of complex confined spaces, but in practice, the body's stiffness and contact friction often require experimental adjustments. Here, for the first time, we develop a...
European journal of medicinal chemistry
Sep 30, 2025
Delivering small molecules to the brain and central nervous system (CNS) is greatly hindered by the restrictive blood-brain barrier (BBB), which selectively permits essential molecules while excluding toxic molecules. This selective permeability feat...
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