Therapeutic options for refractory depression are urgently needed. We conducted a deep brain stimulation (DBS) randomized controlled trial of the bed nucleus of the stria terminalis (BNST), an extended amygdala structure, and nucleus accumbens (NAc) ...
Recent computational, pre-clinical, and clinical studies have demonstrated the potential for using neuromodulation through simultaneous targeting of multiple deep brain regions. This approach has already been used for therapeutic and systems neurosci...
Depression is a significant public health issue, consistently ranking among the leading causes of mortality, reduced quality of life, and economic burden. Despite available treatments, approximately one-third of patients exhibit resistance to standar...
Closed-loop neural stimulation provides novel therapies for neurological diseases such as Parkinson's disease (PD), but it is not yet clear whether artificial intelligence (AI) techniques can tailor closed-loop stimulation to individual patients or i...
Subthalamic deep brain stimulation (STN-DBS) provides unprecedented spatiotemporal precision for the treatment of Parkinson's disease (PD), allowing for direct real-time state-specific adjustments. Inspired by findings from optogenetic stimulation in...
BACKGROUND: Recently, robotic arms have been incorporated into the implantation of electrodes for deep brain stimulation (DBS).This study aimed to determine the accuracy of brain electrode placement, initial clinical efficacy, and safety profile of t...
Personalized stimulation, in which algorithms used to detect neural events adapt to a user's unique neural characteristics, may be crucial to enable optimized and consistent stimulation quality for both fundamental research and clinical applications....
The human thalamus projects nerve fibers to all cortical regions and propagates epileptic activity. However, opportunities to directly record thalamic and cortical neural activities simultaneously are extremely limited and their electrophysiological ...
Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
Jun 18, 2025
BACKGROUND: Generative artificial intelligence (AI) in deep brain stimulation (DBS) is currently unvalidated in its content. This study sought to analyze AI responses to questions and recommendations from the 2018 Congress of Neurological Surgeons (C...
INTRODUCTION: Epilepsy is a prevalent chronic neurological disorder, with approximately one-third of patients experiencing intractable epilepsy, often necessitating surgical intervention. Deep brain stimulation (DBS) of the thalamus has been introduc...
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