BACKGROUND: Previous studies have suggested deep learning to be a highly effective approach for screening lead compounds for new drugs. Several deep learning models have been developed by addressing the use of various kinds of fingerprints and graph ...
BACKGROUND: N6-methyladensine (m6A) is a common and abundant RNA methylation modification found in various species. As a type of post-transcriptional methylation, m6A plays an important role in diverse RNA activities such as alternative splicing, an ...
Computer methods and programs in biomedicine
Dec 29, 2018
BACKGROUND AND OBJECTIVE: Prostate segmentation on Magnetic Resonance (MR) imaging is problematic because disease changes the shape and boundaries of the gland and it can be difficult to separate the prostate from surrounding tissues. We propose an a...
Theoretical biology & medical modelling
Dec 29, 2018
BACKGROUND: The Smad7 protein is negative regulator of the TGF-β signaling pathway, which is upregulated in patients with breast cancer. miRNAs regulate proteins expressions by arresting or degrading the mRNAs. The purpose of this work is to identify...
PURPOSE: Patient-specific quality assurance (QA) for intensity-modulated radiation therapy (IMRT) is a ubiquitous clinical procedure, but conventional methods have often been criticized as being insensitive to errors or less effective than other comm...
BACKGROUND: Adverse drug reactions (ADRs) are unintended and harmful reactions caused by normal uses of drugs. Predicting and preventing ADRs in the early stage of the drug development pipeline can help to enhance drug safety and reduce financial cos...
BACKGROUND: A range of rare and common genetic variants have been discovered to be potentially associated with mental diseases, but many more have not been uncovered. Powerful integrative methods are needed to systematically prioritize both variants ...
IEEE transactions on bio-medical engineering
Dec 27, 2018
The use of deep neural networks for biomedical image analysis requires a sufficient number of labeled datasets. To acquire accurate labels as the gold standard, multiple observers with specific expertise are required for both annotation and proofread...
In recent decades stereology-based studies have played a significant role in understanding brain aging and developing novel drug discovery strategies for treatment of neurological disease and mental illness. A major obstacle to further progress in a ...
BACKGROUND: Exon splicing is a regulated cellular process in the transcription of protein-coding genes. Technological advancements and cost reductions in RNA sequencing have made quantitative and qualitative assessments of the transcriptome both poss...
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