International journal of biological macromolecules
Jun 1, 2025
The N6-methyladenosine(m6A) modification plays crucial regulatory roles in various biological processes including gene expression regulation, RNA stability, splicing, and translation. Accurate prediction of m6A modification sites is essential for und...
This study employs Convolutional Neural Networks (CNNs) as feature extractors with appended regression layers for the non-invasive prediction of Cobb Angle (CA) from Surface Topography (ST) scans in adolescents with Idiopathic Scoliosis (AIS). The ai...
International journal of biological macromolecules
Jun 1, 2025
Recent advances in machine learning have revolutionized molecular design; however, a gap remains in integrating generative models with physics-based simulations to develop functional modulators, such as stable peptides, for challenging targets like t...
Journal of evaluation in clinical practice
Jun 1, 2025
BACKGROUND: Over the past 20 years, researchers have concentrated on generating retinal images as a means of detecting and classifying chronic diseases. Early diagnosis and treatment are essential to avoid chronic diseases. Manually grading retinal i...
PURPOSE: Modern intensity-modulated radiotherapy, aiming to deliver an accurate dose to the planning target volume while protecting the surrounding organs at risk, is regarded as the indispensable treatment for cancer in the clinic. An accurate and e...
Se pu = Chinese journal of chromatography
Jun 1, 2025
Gel electrophoresis is used to separate and analyze macromolecules （such as DNA， RNA， and proteins） and their fragments， and highly reproducible and efficient automatic band-detection methods have been developed to analyze gel images. Uneven backgrou...
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Jun 1, 2025
The clinical benefits of neoadjuvant chemoimmunotherapy (NACI) are demonstrated in patients with bladder cancer (BCa); however, more than half fail to achieve a pathological complete response (pCR). This study utilizes multi-center cohorts of 2322 pa...
Regulation of DNA or RNA at the transcriptional, post-transcriptional, and translational levels are key steps in the central dogma of molecular biology. DNA-binding proteins (DBPs) and RNA-binding proteins (RBPs) play pivotal roles in the precise reg...
Alzheimer's disease (AD) is a progressive neurological disorder characterized by cognitive decline due to brain cell death, typically manifesting later in life.Early and accurate detection is critical for effective disease management and treatment. T...
The application of AI for predicting critical heart failure endpoints using echocardiography is a promising avenue to improve patient care and treatment planning. However, fully supervised training of deep learning models in medical imaging requires ...
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