Fish embryo models are widely used as screening tools to assess the efficacy and/or toxicity of chemicals. This assessment involves the analysis of embryo morphological abnormalities. In this article, we propose a multi-scale pipeline to allow automa...
We have designed and constructed a Flipping Stage for a light microscope that can view the whole exterior surface of a 2 mm diameter developing axolotl salamander embryo. It works by rapidly inverting the bottom-heavy embryo, imaging it as it rights ...
Biochimica et biophysica acta. Proteins and proteomics
Sep 30, 2017
The development of new microscopy techniques for super-resolved, long-term monitoring of cellular and subcellular dynamics in living organisms is revealing new fundamental aspects of tissue development and repair. However, new microscopy approaches p...
Pesticide biochemistry and physiology
Aug 31, 2017
Bacillus is the most widely studied biocontrol agent and has been extensively used in the development of biopesticides and fungicides. In this study, a new cyclic lipopeptide was isolated from Bacillus amyloliquefaciens HAB-2 by column chromatography...
Materials science & engineering. C, Materials for biological applications
Dec 23, 2016
The aim of this study was to evaluate the anticancer activity of bioinspired silver nanoparticles (AgNPs) and gold nanoparticles (AuNPs) against mouse myoblast cancer cells (CC). Both AgNPs and AuNPs were biologically synthesized using Spinacia olera...
Early brain connectivity development consists of multiple stages: birth of neurons, their migration and the subsequent growth of axons and dendrites. Each stage occurs within a certain period of time depending on types of neurons and cortical layers....
Neural networks : the official journal of the International Neural Network Society
Sep 1, 2014
In this study, we propose a continuous model for a pathfinding system. We consider acyclic graphs whose vertices are connected by unidirectional edges. The proposed model autonomously finds a path connecting two specified vertices, and the path is re...
Aquatic toxicology (Amsterdam, Netherlands)
Aug 1, 2025
Screening chemicals using the zebrafish embryo developmental toxicity assay requires visual assessment of larval morphological changes based on images by experienced screeners. The process is time-consuming and prone to subjectivity. However, deep le...
Speckle noises widely exist in optical coherence tomography (OCT) images. We propose an improved double-path parallel convolutional neural network (called DPNet) to reduce speckles. We increase the network width to replace the network depth to extrac...
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