AIMC Topic: ErbB Receptors

Clear Filters Showing 71 to 80 of 82 articles

[Exploration of the Predictive Value of Peripheral Blood-related Indicators for EGFR 
Mutations and Prognosis in Non-small Cell Lung Cancer Using Machine Learning].

Zhongguo fei ai za zhi = Chinese journal of lung cancer Feb 20, 2025
BACKGROUND: Epidermal growth factor receptor (EGFR) sensitive mutation is one of the effective targets of targeted therapy for non-small cell lung cancer (NSCLC). However, due to the difficulty of obtaining some primary tissues and the economic facto...
Female Aged Adult Machine Learning Prognosis Retrospective Studies Lung Neoplasms Carcinoma, Non-Small-Cell Lung Mutation ErbB Receptors Biomarkers, Tumor Male Middle Aged Humans
View on PubMed DOI

Deep learning-based analysis of EGFR mutation prevalence in lung adenocarcinoma H&E whole slide images.

The journal of pathology. Clinical research Nov 1, 2024
EGFR mutations are a major prognostic factor in lung adenocarcinoma. However, current detection methods require sufficient samples and are costly. Deep learning is promising for mutation prediction in histopathological image analysis but has limitati...
Lung Neoplasms Humans Adenocarcinoma of Lung Female Mutation DNA Mutational Analysis Image Interpretation, Computer-Assisted Deep Learning ErbB Receptors
View on PubMed DOI

D3EGFR: a webserver for deep learning-guided drug sensitivity prediction and drug response information retrieval for EGFR mutation-driven lung cancer.

Briefings in bioinformatics Mar 27, 2024
As key oncogenic drivers in non-small-cell lung cancer (NSCLC), various mutations in the epidermal growth factor receptor (EGFR) with variable drug sensitivities have been a major obstacle for precision medicine. To achieve clinical-level drug recomm...
Humans Deep Learning Lung Neoplasms Carcinoma, Non-Small-Cell Lung Mutation Information Storage and Retrieval ErbB Receptors
View on PubMed DOI

Deep learning-based classification of breast cancer cells using transmembrane receptor dynamics.

Bioinformatics (Oxford, England) Dec 22, 2021
MOTIVATION: Motions of transmembrane receptors on cancer cell surfaces can reveal biophysical features of the cancer cells, thus providing a method for characterizing cancer cell phenotypes. While conventional analysis of receptor motions in the cell...
Breast Neoplasms Deep Learning Cell Line, Tumor Humans Female MCF-7 Cells Epithelial-Mesenchymal Transition ErbB Receptors
View on PubMed DOI

Deep neural networks identify signaling mechanisms of ErbB-family drug resistance from a continuous cell morphology space.

Cell reports Jan 19, 2021
It is well known that the development of drug resistance in cancer cells can lead to changes in cell morphology. Here, we describe the use of deep neural networks to analyze this relationship, demonstrating that complex cell morphologies can encode s...
ErbB Receptors Humans Neural Networks, Computer Signal Transduction Drug Resistance, Neoplasm Machine Learning Deep Learning
View on PubMed DOI

TMLRpred: A machine learning classification model to distinguish reversible EGFR double mutant inhibitors.

Chemical biology & drug design Sep 1, 2020
The EGFR is a clinically important therapeutic drug target in lung cancer. The first-generation tyrosine kinase inhibitors used in clinics are effective against L858R-mutated EGFR. However, relapse of the disease due to the presence of resistant muta...
ErbB Receptors Models, Theoretical Mutation Datasets as Topic Humans Machine Learning
View on PubMed DOI

Next-Generation Radiogenomics Sequencing for Prediction of EGFR and KRAS Mutation Status in NSCLC Patients Using Multimodal Imaging and Machine Learning Algorithms.

Molecular imaging and biology Aug 1, 2020
PURPOSE: Considerable progress has been made in the assessment and management of non-small cell lung cancer (NSCLC) patients based on mutation status in the epidermal growth factor receptor (EGFR) and Kirsten rat sarcoma viral oncogene (KRAS). At the...
Proto-Oncogene Proteins p21(ras) Machine Learning Algorithms Humans Multimodal Imaging Area Under Curve Mutation Multivariate Analysis Lung Neoplasms ErbB Receptors Female Positron-Emission Tomography Genomics Aged High-Throughput Nucleotide Sequencing Carcinoma, Non-Small-Cell Lung Male
View on PubMed DOI

[Prediction of gene mutation in lung cancer based on deep learning and histomorphology analysis].

Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi Feb 25, 2020
Lung cancer is a most common malignant tumor of the lung and is the cancer with the highest morbidity and mortality worldwide. For patients with advanced non-small cell lung cancer who have undergone epidermal growth factor receptor (EGFR) gene mutat...
Lung Neoplasms Carcinoma, Non-Small-Cell Lung Mutation ErbB Receptors Humans Deep Learning
View on PubMed DOI

Validity of Natural Language Processing for Ascertainment of and Test Results in SEER Cases of Stage IV Non-Small-Cell Lung Cancer.

JCO clinical cancer informatics May 1, 2019
PURPOSE: SEER registries do not report results of epidermal growth factor receptor () and anaplastic lymphoma kinase () mutation tests. To facilitate population-based research in molecularly defined subgroups of non-small-cell lung cancer (NSCLC), we...
Anaplastic Lymphoma Kinase DNA Mutational Analysis Kentucky ErbB Receptors Humans Machine Learning Algorithms Female Male Middle Aged Reproducibility of Results Lung Neoplasms Aged Adult Carcinoma, Non-Small-Cell Lung Population Surveillance Natural Language Processing Genetic Testing SEER Program Mutation Registries
View on PubMed DOI

KAI1/CD82, Metastasis Suppressor Gene as a Therapeutic Target for Non-Small-Cell Lung Carcinoma.

Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer Jan 1, 2017
Lung cancer is the most frequent malignancy and the leading cause of cancer-related death worldwide; it is the second most common cancer, comprising 1.69 million deaths worldwide per year. Among these, 85% of lung cancers are non-small-cell lung carc...
Genes, p53 ErbB Receptors Humans Kangai-1 Protein Wnt Signaling Pathway Lung Neoplasms Genes, Tumor Suppressor Carcinoma, Non-Small-Cell Lung
View on PubMed DOI
Popular Topics
Recent Journals