AIMC Topic: False Positive Reactions

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Small lung nodules detection based on local variance analysis and probabilistic neural network.

Computer methods and programs in biomedicine
BACKGROUND AND OBJECTIVE: In medical examinations doctors use various techniques in order to provide to the patients an accurate analysis of their actual state of health. One of the commonly used methodologies is the x-ray screening. This examination...

Detection of white matter lesion regions in MRI using SLIC0 and convolutional neural network.

Computer methods and programs in biomedicine
BACKGROUND AND OBJECTIVE: White matter lesions are non-static brain lesions that have a prevalence rate up to 98% in the elderly population. Because they may be associated with several brain diseases, it is important that they are detected as soon as...

Detecting Opioid-Related Aberrant Behavior using Natural Language Processing.

AMIA ... Annual Symposium proceedings. AMIA Symposium
The United States is in the midst of a prescription opioid epidemic, with the number of yearly opioid-related overdose deaths increasing almost fourfold since 2000. To more effectively prevent unintentional opioid overdoses, the medical profession re...

A hybrid model based on neural networks for biomedical relation extraction.

Journal of biomedical informatics
Biomedical relation extraction can automatically extract high-quality biomedical relations from biomedical texts, which is a vital step for the mining of biomedical knowledge hidden in the literature. Recurrent neural networks (RNNs) and convolutiona...

A deep 3D residual CNN for false-positive reduction in pulmonary nodule detection.

Medical physics
PURPOSE: The automatic detection of pulmonary nodules using CT scans improves the efficiency of lung cancer diagnosis, and false-positive reduction plays a significant role in the detection. In this paper, we focus on the false-positive reduction tas...

Computational Prediction of Sigma-54 Promoters in Bacterial Genomes by Integrating Motif Finding and Machine Learning Strategies.

IEEE/ACM transactions on computational biology and bioinformatics
Sigma factor, as a unit of RNA polymerase holoenzyme, is a critical factor in the process of gene transcriptional regulation. It recognizes the specific DNA sites and brings the core enzyme of RNA polymerase to the upstream regions of target genes. T...

Predicting urinary tract infections in the emergency department with machine learning.

PloS one
BACKGROUND: Urinary tract infection (UTI) is a common emergency department (ED) diagnosis with reported high diagnostic error rates. Because a urine culture, part of the gold standard for diagnosis of UTI, is usually not available for 24-48 hours aft...

Classification of the Clinical Images for Benign and Malignant Cutaneous Tumors Using a Deep Learning Algorithm.

The Journal of investigative dermatology
We tested the use of a deep learning algorithm to classify the clinical images of 12 skin diseases-basal cell carcinoma, squamous cell carcinoma, intraepithelial carcinoma, actinic keratosis, seborrheic keratosis, malignant melanoma, melanocytic nevu...

Hit Dexter: A Machine-Learning Model for the Prediction of Frequent Hitters.

ChemMedChem
False-positive assay readouts caused by badly behaving compounds-frequent hitters, pan-assay interference compounds (PAINS), aggregators, and others-continue to pose a major challenge to experimental screening. There are only a few in silico methods ...

Prediction of GPCR-Ligand Binding Using Machine Learning Algorithms.

Computational and mathematical methods in medicine
We propose a novel method that predicts binding of G-protein coupled receptors (GPCRs) and ligands. The proposed method uses hub and cycle structures of ligands and amino acid motif sequences of GPCRs, rather than the 3D structure of a receptor or si...