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Broadly active intranasal influenza vaccine with a nanocomplex particulate adjuvant targeting mast cells and toll-like receptor 9.

Journal of controlled release : official journal of the Controlled Release Society
Flumist is the only FDA-approved intranasal influenza vaccine. Although it has recently been approved for at-home use, it has significant limitations. These include reduced effectiveness in generating a protective immune response in patients with ext...

Fractal analysis for cognitive impairment classification in DAVF using machine learning.

Biomedical physics & engineering express
. Intracranial dural arteriovenous fistula (DAVF) is an acquired vascular condition involving abnormal connections between dural arteries and veins without intervening capillary beds. Cognitive impairment is a common symptom in DAVFs, often linked to...

Factors Shaping Healthcare Professionals' Perceptions of AI in Saudi Arabia: A Cross-Sectional Study.

Studies in health technology and informatics
The successful adoption of artificial intelligence (AI) in healthcare relies on healthcare professionals' perceptions of its usefulness and their preparedness to integrate it into their practice. This study explores factors influencing these percepti...

Supporting Personalized prEgnancy Care wIth Artificial inteLligence (SPECIAL): An Acceptability Study of a Personalized Educational Platform.

Studies in health technology and informatics
Postpartum depression (PPD) affects approximately 20% of pregnant individuals, yet half of these cases remain under-treated despite the availability of educational interventions. To address this gap, the Supporting Personalized prEgnancy Care wIth Ar...

End Users' Perception on an AI Chatbot in a Snus Cessation Mobile Application.

Studies in health technology and informatics
This study examines end-user perceptions of an AI chatbot as a virtual therapist through a design study of ExSnus, a prototype of a mobile health application designed to assist users in quitting snus. ExSnus includes features such as a forum to share...

Chronic Pain Prevalence, Opioid Use, and Primary Care Provider Opioid Prescription Patterns in the U.S. from 2017 to 2019 Derived from Medicaid Claims Data.

Studies in health technology and informatics
Chronic non-cancer pain (CNCP) is a major health concern in the United States, incurring substantial healthcare costs and frequently requiring opioid therapy in primary care. This retrospective cross-sectional study used Medicaid claims data from six...

Early Identification of Vitamin D Deficiency Risk Through Public Health Screening Data.

Studies in health technology and informatics
Metabolic syndrome, characterized by central obesity, hypertension, hyperglycemia, dyslipidemia, and reduced high-density lipoprotein levels, significantly increases the risk of cardiovascular diseases. Vitamin D, essential for calcium regulation and...

Algorithmic Fairness in Machine Learning Prediction of Autism Using Electronic Health Records.

Studies in health technology and informatics
Efforts to improve early diagnosis of autism spectrum disorder (ASD) in children are beginning to use machine learning (ML) approaches applied to real-world clinical datasets, such as electronic health records (EHRs). However, sex-based disparities i...

Personalized Prediction of Chronic Kidney Disease Progression in Patients with Chronic Kidney Disease Stages 3-5: A Multicenter Study Using the Machine Learning Approach.

Studies in health technology and informatics
Chronic Kidney Disease (CKD) is a prevalent and progressive condition that can lead to end-stage renal disease (ESRD) if left unmanaged. Accurate prediction of CKD progression, particularly in patients with CKD stages 3-5, is essential for early inte...

Early Detection of Acute Coronary Syndrome Using a Mobile Digital Health Application.

Studies in health technology and informatics
Early detection of acute coronary syndrome (ACS) is vital for reducing ischemic time and preserving more heart muscle.Chest pain is the most common symptom of acute coronary syndrome (ACS). This study used a quick chest pain assessment questionnaire ...