BACKGROUND: Asthma is a heterogeneous and complex disease in both its clinical course and response to treatment. IL-13 is central to Type 2 inflammation and contributes to many features of asthma. In a previous Phase 2 study, lebrikizumab, an anti-IL...
BACKGROUND: The contribution of fluticasone furoate (FF) on lung function in the FF/vilanterol (VI) 100/25 μg combination has been demonstrated numerically, but not statistically.
BACKGROUND: In lymphangioleiomyomatosis (LAM), predicting lung disease progression is essential for treatment planning. However, no previous Japanese studies have attempted to predict the reductions in pulmonary function that occur in LAM patients.
Annals of the American Thoracic Society
Nov 1, 2025
Deployment to the Southwest Asia theater of military operations is associated with new-onset respiratory symptoms, yet commonly used parameters on pulmonary function testing (PFT) are typically reported to be within the normal range for most deploye...
American journal of respiratory and critical care medicine
Sep 1, 2025
Small airway dysfunction (SAD) is a key feature of chronic obstructive pulmonary disease and might present in tobacco-exposed adults with normal spirometry. So far, the role of oscillometry-defined SAD in this population is largely unexplored. To i...
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a common and progressive respiratory condition characterized by persistent airflow limitation and symptoms such as dyspnea, cough, and sputum production. Acute exacerbations (AE) of COPD (AE...
The Journal of the Association of Physicians of India
Sep 1, 2023
BACKGROUND: Asthma COPD overlap (ACO) is a consensus-based phenotype having characteristics of both COPD and asthma. Distinguishing ACO from other diseases is even more important as it is related to low health-related quality of life, augmented exace...
BACKGROUND: In spirometry, the area under expiratory flow-volume curve (AEX-FV) was found to perform well in diagnosing and stratifying physiologic impairments, potentially lessening the need for complex lung volume testing. Expanding on prior work, ...
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease
Mar 1, 2016
BACKGROUND: Unsupervised learning technique allows researchers to identify different phenotypes of diseases with complex manifestations.
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