BACKGROUND: Patients with rheumatoid arthritis (RA) are more likely to comorbid renal diseases, with membranous nephropathy (MN) being the most common. This study aimed to explore the common pathogenesis between RA and MN using integrated bioinformat...
Gene expression is an important process in which genes guide the synthesis of proteins, and molecular-level differences often lead to individual phenotypic variations. Combining molecular information at the nano-level with phenotypic information at t...
Heterogeneity of breast cancer poses several challenges for detection and treatment. With next-generation sequencing, we can now map the transcriptional profile of each patient's breast tissue, which has the potential for identifying and characterizi...
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
Jul 22, 2025
This study explores the therapeutic targets and mechanisms of Gynostemma pentaphyllum in non-alcoholic fatty liver disease (NAFLD). Using network analysis and bioinformatics, we identified target genes of Gynostemma's active metabolites in NAFLD thro...
Chloride channel accessory 1 (CLCA1) is considered a potential prognostic biomarker for colon adenocarcinoma (COAD). The objective of this research was to develop two pathomics models to predict CLCA1 expression from hematoxylin-eosin (H&E) stained p...
Cerebral amyloid angiopathy (CAA) and insomnia are age-related neurological disorders increasingly recognized as being closely associated. However, research on the shared genes and their biological mechanisms remains limited. This study aims to ident...
Acute myocardial infarction (AMI) is a serious heart disease with high fatality rates. The progress of AMI involves immune cell infiltration. However, suitable clinical diagnostic biomarkers and the roles of immune cells in AMI remain unknown. Three ...
Pulpal inflammation and regeneration are crucial for enhancing endodontic treatment outcomes. Transcriptomic studies highlight the involvement of proinflammatory cytokines, NF-κB signaling, and stem cell activity. This study employs a generative AI a...
Recent advances in spatial transcriptomics technologies have enabled gene expression profiling across the transcriptome in spots with subcellular resolution, but high sparsity and dimensionality present significant computational challenges. We presen...
DNA metabolism genes play pivotal roles in the regulation of cellular processes that contribute to cancer progression, immune modulation, and therapeutic response in prostate cancer (PC). Understanding the mechanisms by which these genes influence th...
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