This study aimed to comprehensively investigate the regulatory mechanism and clinical value of secreted phosphoprotein 1 (SPP1) in the three-stage progression of "smoking-chronic obstructive pulmonary disease (COPD)-carcinogenesis" in lung squamous ...
OBJECTIVE: Diagnosis of hepatocellular carcinoma (HCC) remains challenging for clinicians. Machine learning approaches and big data analyses are viable strategies for identifying HCC diagnostic markers.
Artificial cells, nanomedicine, and biotechnology
Dec 1, 2025
Gastric cancer remains one of the deadliest cancers globally due to delayed detection and limited treatment options, underscoring the critical need for innovative prognostic methods. Disulfidptosis, a recently discovered programmed cell death trigger...
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Nov 15, 2025
We pioneer a multimodal framework integrating single-cell RNA sequencing (scRNA-seq), radiomics, and deep learning to decipher dendritic cell (DC)-mediated mechanisms underlying anti-PD-1 response in non-small cell lung cancer (NSCLC). Single-cell RN...
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Oct 31, 2025
Protein arginine methylation was a common post-translational modification, playing a key role in many biological processes and disease. But the regulatory mechanisms of protein arginine methyltransferases (PRMTs) in cancer were not well understood. T...
The incidence of hepatocellular carcinoma (HCC) has risen significantly in recent years, while current diagnostic and therapeutic approaches remain suboptimal. This study aimed to identify novel biomarkers and therapeutic targets to improve early det...
UNLABELLED: tRNA-derived fragments (tRF) are a class of small noncoding RNAs that have exhibited several functions in cancer. Recent studies have shown that mutations in tRNA genes can lead to global changes in tRF expression levels and may affect tR...
UNLABELLED: Alterations to N6-methyladenosine (m6A) modifications can promote malignant progression by modulating gene expression through regulation of transcript metabolism. Quantifying the causal impact of m6A dysregulation at the population level ...
BACKGROUND: Considerable evidence highlights the intricate association between liquid-liquid phase separation (LLPS) and tumorigenesis, progression, and therapy resistance. However, there has been limited exploration of the role of LLPS in hepatoblas...
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