AIMC Topic: Glomerulonephritis, Membranous

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Multi-omics insights of immune cells in the risk and prognosis of idiopathic membranous nephropathy.

Communications biology
Idiopathic membranous nephropathy (IMN) is the major cause of autoimmune-related nephrotic syndrome. The role immune cells play in the risk and prognosis of IMN remains elusive. We employ multi-omics data and a variety of approaches to evaluate the c...

Exploring the comorbidity mechanisms of ITGB2 in rheumatoid arthritis and membranous nephropathy through integrated bioinformatics analysis.

Renal failure
BACKGROUND: Patients with rheumatoid arthritis (RA) are more likely to comorbid renal diseases, with membranous nephropathy (MN) being the most common. This study aimed to explore the common pathogenesis between RA and MN using integrated bioinformat...

Multimodal deep learning improving the accuracy of pathological diagnoses for membranous nephropathy.

Renal failure
OBJECTIVES: Renal biopsy is the gold standard for the diagnosis of glomerular diseases including membranous nephropathy (MN), however, it faces challenges in accuracy, objectivity, and reproducibility of tissue evaluation. This study aims to develop ...

Rapid diagnosis of membranous nephropathy based on kidney tissue Raman spectroscopy and deep learning.

Scientific reports
Membranous nephropathy (MN) is one of the most common glomerular diseases. Although the diagnostic method based on serum PLA2R antibodies has gradually been applied in clinical practice, only 52-86% of PLA2R-associated MN patients show positive anti-...

Artificial intelligence-based personalised rituximab treatment protocol in membranous nephropathy (iRITUX): protocol for a multicentre randomised control trial.

BMJ open
INTRODUCTION: Membranous nephropathy is an autoimmune kidney disease and the most common cause of nephrotic syndrome in non-diabetic Caucasian adults. Rituximab is now recommended as first-line therapy for membranous nephropathy. However, Kidney Dise...

Self-Supervised Learning for Feature Extraction from Glomerular Images and Disease Classification with Minimal Annotations.

Journal of the American Society of Nephrology : JASN
BACKGROUND: Deep learning has great potential in digital kidney pathology. However, its effectiveness depends heavily on the availability of extensively labeled datasets, which are often limited because of the specialized knowledge and time required ...

Effects of tacrolimus on proteinuria in Chinese and Indian patients with idiopathic membranous nephropathy: the results of machine learning study.

International urology and nephrology
PURPOSE: The present study aims to explore the effects of tacrolimus on proteinuria in patients with idiopathic membranous nephropathy (IMN) and recommend an appropriate dosage schedule via machine learning method.

Prediction of immunotherapy response in idiopathic membranous nephropathy using deep learning-pathological and clinical factors.

Frontiers in endocrinology
BACKGROUND: Owing to individual heterogeneity, patients with idiopathic membranous nephropathy (IMN) exhibit varying sensitivities to immunotherapy. This study aimed to establish and validate a model incorporating pathological and clinical features u...

Rapid diagnosis of membranous nephropathy based on serum and urine Raman spectroscopy combined with deep learning methods.

Scientific reports
Membranous nephropathy is the main cause of nephrotic syndrome, which has an insidious onset and may progress to end-stage renal disease with a high mortality rate, such as renal failure and uremia. At present, the diagnosis of membranous nephropathy...