AIMC Topic: Hepatitis B virus
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Machine-learning based patient classification using Hepatitis B virus full-length genome quasispecies from Asian and European cohorts.
Scientific reports
Dec 11, 2019
Chronic infection with Hepatitis B virus (HBV) is a major risk factor for the development of advanced liver disease including fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). The relative contribution of virological factors to disease progres...
Booster immunity - diagnosis of chronic hepatitis B viral infection.
Journal of infection in developing countries
Mar 31, 2019
INTRODUCTION: Diagnosis of chronic hepatitis B virus (HBV) infection particularly its occult form requires monitoring and repeat serological and molecular studies. The aim of the study was to investigate the possible relation between the case of a fa...
Application of recurrent neural network for online prediction of cell density of recombinant Pichia pastoris producing HBsAg.
Preparative biochemistry & biotechnology
Feb 1, 2019
Artificial neural networking (ANN) seems to be a promising soft sensor for implementing current approaches of quality by design (QbD) and process analytical technologies (PAT) in the biopharmaceutical industry. In this study, we aimed to implement be...
Clinical prediction of HBV and HCV related hepatic fibrosis using machine learning.
EBioMedicine
Aug 10, 2018
Clinical prediction of advanced hepatic fibrosis (HF) and cirrhosis has long been challenging due to the gold standard, liver biopsy, being an invasive approach with certain limitations. Less invasive blood test tandem with a cutting-edge machine lea...
Long-term incidence and predictors of hepatitis B surface antigen loss after discontinuing nucleoside analogues in noncirrhotic chronic hepatitis B patients.
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
Dec 26, 2017
OBJECTIVE: To investigate the long-term incidence and predictors for hepatitis B surface antigen (HBsAg) loss after nucleoside analogue therapy.
A European multicenter study on the analytical performance of the VERIS HBV assay.
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology
Dec 19, 2017
BACKGROUND: Hepatitis B viral load monitoring is an essential part of managing patients with chronic Hepatits B infection. Beckman Coulter has developed the VERIS HBV Assay for use on the fully automated Beckman Coulter DxN VERIS Molecular Diagnostic...
Development and validation of an LC-MS/MS method for quantification of NC-8 in rat plasma and its application to pharmacokinetic studies.
Journal of food and drug analysis
Nov 11, 2017
ent-16-Oxobeyeran-19-N-methylureido (NC-8) is a recently synthesized derivative of isosteviol that showed anti-hepatitis B virus (HBV) activity by disturbing replication and gene expression of the HBV and by inhibiting the host toll-like receptor 2/n...
A machine learning approach for viral genome classification.
BMC bioinformatics
Apr 11, 2017
BACKGROUND: Advances in cloning and sequencing technology are yielding a massive number of viral genomes. The classification and annotation of these genomes constitute important assets in the discovery of genomic variability, taxonomic characteristic...
An ultrasensitive sandwich-type electrochemical immunosensor based on the signal amplification system of double-deck gold film and thionine unite with platinum nanowire inlaid globular SBA-15 microsphere.
Biosensors & bioelectronics
Dec 29, 2016
A novel thionine unites with platinum nanowire inlaid globular SBA-15 (Pt NWs@g-SBA-15/Thi) not only utilizes as an efficient electrical signal probe but also constitutes an amplifying system with double-deck gold film (D-Au film) have been applied t...
Development of chronic hepatitis B infection in a hepatitis B vaccine responder.
International journal of STD & AIDS
Nov 12, 2016
The Hepatitis B vaccine is highly effective for the prevention of hepatitis B (HBV) infection. We report the development of chronic HBV infection (Genotype F) in a vaccinated immunocompetent individual with an anti-HBsAb of 35 mIU/mL post completion ...
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