AIMC Topic: Heterocyclic Compounds, 1-Ring

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Prognostic Value of AI-Assisted Lesion Tracking on End-of-Treatment PSMA PET in mCRPC Patients Treated with Lu-PSMA: A Retrospective, Single-Center Study.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine Nov 3, 2025
This study aimed to explore the prognostic value of the artificial intelligence-assisted lesion tracking applied to prostate-specific membrane antigen (PSMA) PET in patients with metastatic castration-resistant prostate cancer (mCRPC) treated with PS...
Prostate-Specific Antigen Radiopharmaceuticals Positron-Emission Tomography Male Middle Aged Treatment Outcome Antigens, Surface Glutamate Carboxypeptidase II Lutetium Heterocyclic Compounds, 1-Ring Dipeptides Prostatic Neoplasms, Castration-Resistant Radioisotopes Humans Retrospective Studies Artificial Intelligence Aged Prognosis Aged, 80 and over
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Deep Learning for Automated Measures of SUV and Molecular Tumor Volume in [Ga]PSMA-11 or [F]DCFPyL, [F]FDG, and [Lu]Lu-PSMA-617 Imaging with Global Threshold Regional Consensus Network.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine Nov 3, 2025
Metastatic castration-resistant prostate cancer has a high rate of mortality with a limited number of effective treatments after hormone therapy. Radiopharmaceutical therapy with [Lu]Lu-prostate-specific membrane antigen-617 (LuPSMA) is one treatment...
Image Processing, Computer-Assisted Positron Emission Tomography Computed Tomography Prostate-Specific Antigen Male Deep Learning Consensus Fluorodeoxyglucose F18 Oligopeptides Urea Dipeptides Tumor Burden Automation Humans Aged Gallium Isotopes Lutetium Heterocyclic Compounds, 1-Ring Lysine Radioisotopes Gallium Radioisotopes
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Machine learning models for enhanced diagnosis and risk assessment of prostate cancer with Ga-PSMA-617 PET/CT.

European journal of radiology Mar 19, 2025
OBJECTIVE: Prostate cancer (PCa) is highly heterogeneous, making early detection of adverse pathological features crucial for improving patient outcomes. This study aims to predict PCa aggressiveness and identify radiomic and protein biomarkers assoc...
Positron Emission Tomography Computed Tomography Prostatic Neoplasms Prostate-Specific Antigen Radiopharmaceuticals Dipeptides Machine Learning Male Gallium Radioisotopes Retrospective Studies Middle Aged Gallium Isotopes Aged Risk Assessment Heterocyclic Compounds, 1-Ring Aged, 80 and over Humans Sensitivity and Specificity Biomarkers, Tumor
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Multi-modality deep learning-based [Ga]Ga-DOTA-FAPI-04 PET polar map generation: potential value in detecting reactive fibrosis after myocardial infarction.

European journal of nuclear medicine and molecular imaging Jul 26, 2024
PURPOSE: Generating polar map (PM) from [Ga]Ga-DOTA-FAPI-04 PET images is challenging and inaccurate using existing automatic methods that rely on the myocardial anatomical integrity in PET images. This study aims to enhance the accuracy of PM genera...
Fibrosis Positron-Emission Tomography Organometallic Compounds Deep Learning Humans Gallium Radioisotopes Image Processing, Computer-Assisted Aged Heterocyclic Compounds, 1-Ring Myocardial Infarction Female Male Middle Aged
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DOTA: Deep Learning Optimal Transport Approach to Advance Drug Repositioning for Alzheimer's Disease.

Biomolecules Jan 24, 2022
Alzheimer's disease (AD) is the leading cause of age-related dementia, affecting over 5 million people in the United States and incurring a substantial global healthcare cost. Unfortunately, current treatments are only palliative and do not cure AD. ...
Heterocyclic Compounds, 1-Ring United States Humans Drug Repositioning Brain Alzheimer Disease Deep Learning
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Machine Learning-based Dose Prediction in [Lu]Lu-PSMA-617 Therapy by Integrating Biomarkers and Radiomic Features from [Ga]Ga-PSMA-11 Positron Emission Tomography/Computed Tomography.

International journal of radiation oncology, biology, physics Nov 1, 2025
PURPOSE: The study aimed to develop machine learning (ML) models for pretherapy prediction of absorbed doses (ADs) in kidneys and tumoral lesions for patients with metastatic castration-resistant prostate cancer (mCRPC) undergoing [Lu]Lu-PSMA-617 (Lu...
Gallium Radioisotopes Gallium Isotopes Lutetium Heterocyclic Compounds, 1-Ring Monte Carlo Method Radioisotopes Organometallic Compounds Dipeptides Prostatic Neoplasms, Castration-Resistant Radiotherapy Dosage Biomarkers, Tumor Machine Learning Male Aged Radiomics Middle Aged Humans Prostate-Specific Antigen Kidney Radiopharmaceuticals Positron Emission Tomography Computed Tomography
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