AIMC Topic: Hippocampus
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An Asynchronous Recurrent Network of Cellular Automaton-Based Neurons and Its Reproduction of Spiking Neural Network Activities.
IEEE transactions on neural networks and learning systems
May 13, 2015
Modeling and implementation approaches for the reproduction of input-output relationships in biological nervous tissues contribute to the development of engineering and clinical applications. However, because of high nonlinearity, the traditional mod...
Discrimination of schizophrenia auditory hallucinators by machine learning of resting-state functional MRI.
International journal of neural systems
Jan 19, 2015
Auditory hallucinations (AH) are a symptom that is most often associated with schizophrenia, but patients with other neuropsychiatric conditions, and even a small percentage of healthy individuals, may also experience AH. Elucidating the neural mecha...
Short-term plasticity based network model of place cells dynamics.
Hippocampus
Sep 25, 2014
Rodent hippocampus exhibits strikingly different regimes of population activity in different behavioral states. During locomotion, hippocampal activity oscillates at theta frequency (5-12 Hz) and cells fire at specific locations in the environment, t...
A hierarchical model of goal directed navigation selects trajectories in a visual environment.
Neurobiology of learning and memory
Jul 29, 2014
We have developed a Hierarchical Look-Ahead Trajectory Model (HiLAM) that incorporates the firing pattern of medial entorhinal grid cells in a planning circuit that includes interactions with hippocampus and prefrontal cortex. We show the model's fle...
Redefining diagnostic lesional status in temporal lobe epilepsy with artificial intelligence.
Brain : a journal of neurology
Jun 3, 2025
Despite decades of advancements in diagnostic MRI, 30%-50% of temporal lobe epilepsy (TLE) patients remain categorized as 'non-lesional' (i.e. MRI negative) based on visual assessment by human experts. MRI-negative patients face diagnostic uncertaint...
Machine learning prediction prior to onset of mild cognitive impairment using T1-weighted magnetic resonance imaging radiomic of the hippocampus.
Asian journal of psychiatry
Jun 1, 2025
BACKGROUND: Early identification of individuals who progress from normal cognition (NC) to mild cognitive impairment (MCI) may help prevent cognitive decline. We aimed to build predictive models using radiomic features of the bilateral hippocampus in...
Hippocampal-prefrontal functional neural networks in a rat model of fragile X syndrome are poorly organized with limited resiliency.
Scientific reports
May 8, 2025
Fragile X Syndrome (FXS) is a common cause of autism spectrum symptoms. The genetic mutation results in multiple molecular alterations that are hypothesized to negatively impact neural circuit development although the nature of any functional neural ...
Cross study transcriptomic investigation of Alzheimer's brain tissue discoveries and limitations.
Scientific reports
May 8, 2025
Developing effective treatments for Alzheimer's disease (AD) likely requires a deep understanding of molecular mechanisms. Integration of transcriptomic datasets and developing innovative computational analyses may yield novel molecular targets with ...
Amelioration of Chronic Ethanol Administration-Induced Learning and Memory Impairments by High-Intensity Interval Training (HIIT) and Ritalin.
Brain and behavior
May 1, 2025
OBJECTIVES: The current study aimed to investigate the impacts of 8-week high-intensity interval training (HIIT) and Ritalin (RIT), alone and in combination, on cognitive functions and hippocampal oxidative parameters following chronic ethanol consum...
Evaluating Traditional, Deep Learning and Subfield Methods for Automatically Segmenting the Hippocampus From MRI.
Human brain mapping
Apr 1, 2025
Given the relationship between hippocampal atrophy and cognitive impairment in various pathological conditions, hippocampus segmentation from MRI is an important task in neuroimaging. Manual segmentation, though considered the gold standard, is time-...
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