AIMC Topic: HIV Infections
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Drug Resistance Prediction Using Deep Learning Techniques on HIV-1 Sequence Data.
Viruses
May 19, 2020
The fast replication rate and lack of repair mechanisms of human immunodeficiency virus (HIV) contribute to its high mutation frequency, with some mutations resulting in the evolution of resistance to antiretroviral therapies (ART). As such, studying...
Random forest machine learning algorithm predicts virologic outcomes among HIV infected adults in Lausanne, Switzerland using electronically monitored combined antiretroviral treatment adherence.
AIDS care
Apr 8, 2020
Machine Learning (ML) can improve the analysis of complex and interrelated factors that place adherent people at risk of viral rebound. Our aim was to build ML model to predict RNA viral rebound from medication adherence and clinical data. Patients w...
Comparison of Xpert MTB/RIF (G4) and Xpert Ultra, including trace readouts, for the diagnosis of pulmonary tuberculosis in a TB and HIV endemic setting.
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
Apr 2, 2020
BACKGROUND: There are limited data about Xpert-Ultra performance in different settings, in HIV-infected persons, in those with a history of previous TB, and with trace readouts.
Alendronate/Vitamin D for attenuating bone mineral density loss during antiretroviral initiation: a pilot randomized controlled trial.
HIV research & clinical practice
Feb 27, 2020
Antiretroviral therapy (ART) initiation is associated with decreases in bone mineral density (BMD). To plan for a larger trial, we sought to obtain preliminary estimates for the difference in the change in BMD at 48 weeks achieved with 24 weeks of p...
Vitamin D insufficiency is associated with subclinical atherosclerosis in HIV-1-infected patients on combination antiretroviral therapy.
HIV research & clinical practice
Feb 17, 2020
Vitamin D insufficiency has been associated with faster progression of atherosclerosis and increased cardiovascular disease risk, but limited data are available in HIV-infected people. So, we examined potential correlation between vitamin D status a...
Cenicriviroc, a dual CCR2 and CCR5 antagonist leads to a reduction in plasma fibrotic biomarkers in persons living with HIV on antiretroviral therapy.
HIV research & clinical practice
Feb 4, 2020
Chronic HIV is associated with increased inflammation and tissue fibrosis despite suppressive antiretroviral therapy (ART). Monocytes and macrophages have been implicated in the pathogenesis of fibrosis, facilitated by chemokine receptor interaction...
Characterization of low level viraemia in HIV-infected patients receiving boosted protease inhibitor-based antiretroviral regimens.
HIV research & clinical practice
Jan 30, 2020
To understand the pathogenesis of low level viraemia (LLV) in HIV-infected patients on boosted protease inhibitors (PI/b), we enrolled 34 subjects with a median HIV-RNA 79 copies/mL and followed them for 15 months. Samples for next generation sequenc...
Humans
Female
Adult
Male
Middle Aged
HIV Infections
Viral Load
Mutation
High-Throughput Nucleotide Sequencing
United Kingdom
gag Gene Products, Human Immunodeficiency Virus
Drug Resistance, Multiple, Viral
Viremia
HIV Protease
Anti-Retroviral Agents
HIV Protease Inhibitors
Antiretroviral Therapy, Highly Active
HIV-1
A comparison of machine learning techniques for classification of HIV patients with antiretroviral therapy-induced mitochondrial toxicity from those without mitochondrial toxicity.
BMC medical research methodology
Nov 27, 2019
BACKGROUND: Antiretroviral therapy (ART) has significantly reduced HIV-related morbidity and mortality. However, therapeutic benefit of ART is often limited by delayed drug-associated toxicity. Nucleoside reverse transcriptase inhibitors (NRTIs) are ...
Accurate Prediction for Antibody Resistance of Clinical HIV-1 Isolates.
Scientific reports
Oct 11, 2019
Broadly neutralizing antibodies (bNAbs) targeting the HIV-1 envelope glycoprotein (Env) have promising utility in prevention and treatment of HIV-1 infection, and several are currently undergoing clinical trials. Due to the high sequence diversity an...
Target-Specific Prediction of Ligand Affinity with Structure-Based Interaction Fingerprints.
Journal of chemical information and modeling
Aug 19, 2019
Discovery and optimization of small molecule inhibitors as therapeutic drugs have immensely benefited from rational structure-based drug design. With recent advances in high-resolution structure determination, computational power, and machine learnin...
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