AIMC Topic: Humans

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Stability of Jurkat cells during short-term liquid storage analyzed by flow imaging microscopy.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
The viability of cell-based medicinal products (CBMPs) is a critical quality attribute and must be assessed throughout the product lifecycle to contribute to a safe and potent drug product. In this study, we investigated the impact of short-term liqu...

Predicting hemorrhagic transformation in acute ischemic stroke: a systematic review, meta-analysis, and methodological quality assessment of CT/MRI-based deep learning and radiomics models.

Emergency radiology
Acute ischemic stroke (AIS) is a major cause of mortality and morbidity, with hemorrhagic transformation (HT) as a severe complication. Accurate prediction of HT is essential for optimizing treatment strategies. This review assesses the accuracy and ...

Human bone ultrastructure in 3D: Multimodal correlative study combining nanoscale X-ray computed tomography and quantitative polarized Raman spectroscopy.

Acta biomaterialia
Unique mechanical properties of cortical bone are defined by the arrangement and ratio of its organic and inorganic constituents. This arrangement can be influenced by ageing and disease, urging the understanding of normal and deviant morphological p...

Nanopsychiatry: Advancing psychiatric diagnosis and monitoring through nanotechnology-based detection.

Clinica chimica acta; international journal of clinical chemistry
Nanopsychiatry, operating at the nanoscale, leverages engineered nanomaterials and nanodevices to revolutionize psychiatric diagnostics and therapeutics. This review systematically analyzes the implementation of advanced nanomaterials, including quan...

Artificial intelligence-based virtual staining platform for identifying tumor-associated macrophages from hematoxylin and eosin-stained images.

European journal of cancer (Oxford, England : 1990)
BACKGROUND: Virtual staining is an artificial intelligence-based approach that transforms pathology images between stain types, such as hematoxylin and eosin (H&E) to immunohistochemistry (IHC), providing a tissue-preserving and efficient alternative...

Modelling fourth-order hyperelasticity in soft solids using physics informed neural networks without labelled data.

Brain research bulletin
Mild traumatic brain injury can result from shear shock wave formation in the brain in the event of a head impact like in contact sports, road traffic accidents, etc. These highly nonlinear deformations are modelled by a fourth-order Landau hyperelas...

Breast cancer detection and classification: A study on the specification and implementation of multilayer perceptron analog artificial neural networks.

Computers in biology and medicine
Breast cancer is a leading cause of mortality worldwide. Screening therefore remains the best defense against this disease, highlighting the need for accurate and efficient diagnostic methods. Previous authors addressed this issue by implementing dig...

Role of physics-informed constraints in real-time estimation of 3D vascular fluid dynamics using multi-case neural network.

Computers in biology and medicine
Numerical simulations of fluid dynamics in tube-like structures are important to biomedical research to model flow in blood vessels and airways. It is further useful to some clinical applications, such as predicting arterial fractional flow reserves,...

Distinguishing severe sleep apnea from habitual snoring using a neck-wearable piezoelectric sensor and deep learning: A pilot study.

Computers in biology and medicine
This study explores the development of a deep learning model using a neck-wearable piezoelectric sensor to accurately distinguish severe sleep apnea syndrome (SAS) from habitual snoring, addressing the underdiagnosis of SAS in adults. From 2018 to 20...

Explainable machine learning to identify risk factors for unplanned hospital readmissions in Nova Scotian hospitals.

Computers in biology and medicine
OBJECTIVE: A report from the Canadian Institute for Health Information found unplanned hospital readmissions (UHR) common, costly, and potentially avoidable, estimating a $1.8 billion cost to the Canadian healthcare system associated with inpatient r...