Journal of pharmaceutical and biomedical analysis
Oct 16, 2025
Accurate and rapid diagnosis of Mycoplasma pneumoniae infection is essential for reducing its significant health burden. An amplification-free CRISPR-Cas12a-mediated detection platform has been developed, incorporating a deep learning-optimized crRNA...
BACKGROUND: Depression exhibits significant heterogeneity in antidepressant treatment response. This study aimed to develop an Electroencephalography (EEG)-based machine learning model integrating multidimensional features to predict selective seroto...
Adverse drug reactions (ADRs) remain a major, yet largely preventable, global public health challenge, causing significant morbidity, mortality, and healthcare costs. This review synthesises evidence on the global burden, pharmacovigilance systems, a...
BACKGROUND AND OBJECTIVES: High-dose methylprednisolone (MP) is the global standard for treating pregnancy-associated relapses in multiple sclerosis (MS). Given that glucocorticoids cross the placenta and may interfere with fetal brain development, c...
Membrane curvature is a key biophysical feature that regulates diverse biological processes. A wide range of natural proteins have distinct structural motifs that can sense membrane curvature and function independently as curvature-sensing peptides. ...
Dual-omics, by integrating molecular information from two distinct dimensions, can offer more comprehensive perspective for complex disease. Herein, we developed an efficient functionalized mesoporous nanoparticle-coupled laser desorption/ionization ...
Journal of chemical information and modeling
Oct 16, 2025
The advent of agentic AI systems is leading to significant transformations across scientific and technological domains. Advances in large language models (LLMs), reasoning capabilities, and integration with external tools have ushered in a new era wh...
Proceedings of the National Academy of Sciences of the United States of America
Oct 16, 2025
T cells play a key role in adaptive immunity by mounting specific responses against diverse pathogens. Effective bindings between T cell receptors (TCRs) and pathogen derived peptides presented on major histocompatibility complexes (MHCs) mediate imm...
BACKGROUND: Sepsis is a severe and frequent complication among ischemic stroke patients during hospitalization. The atherogenic index of plasma (AIP), as metabolism-related markers, are closely linked to inflammation. However, their relationship with...
Although goal-concordant care is central to patient-centered medicine, determining treatment preferences for incapacitated patients remains a challenge. Nearly two decades ago, algorithms were proposed to estimate the most likely treatment preference...
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