Journal of the American Chemical Society
Jul 8, 2025
Dynamin-related protein (Drp1) drives mitochondrial fission, dysregulation of which leads to neurodegenerative, metabolic, and apoptotic disorders. The precise mechanism of fission completion is unclear. One prevailing model is based on GTP-driven o...
Journal of the American Chemical Society
Jul 8, 2025
Mitochondrial fission is controlled by dynamin-like proteins, the dysregulation of which is correlated with diverse diseases. Fission dynamin-like proteins are GTP hydrolysis-driven mechanoenzymes that self-oligomerize into helical structures that co...
Proceedings of the National Academy of Sciences of the United States of America
Jul 8, 2025
Glioma is the most common primary malignant brain tumor and preoperative genetic profiling is essential for the management of glioma patients. Our study focused on tumor regions segmentation and predicting the World Health Organization (WHO) grade, i...
Artificial intelligence (AI) is increasingly integrated into health care, offering potential benefits in patient education, triage, and administrative efficiency. This study evaluates AI-driven dialogue interfaces within an electronic health record a...
INTRODUCTION: The role of non-suicidal self-injury (NSSI) in the suicide process of people with major depressive disorder(MDD) remains controversial. Therefore, the purpose of this study was to investigate the role NSSI plays in suicide risk in peopl...
Artificial Intelligence (AI) is rapidly transforming the landscape of critical care, offering opportunities for enhanced diagnostic precision and personalized patient management. However, its integration into ICU clinical practice presents significan...
BACKGROUND: Drug repositioning offers a promising avenue for accelerating drug development and reducing costs. Recently, computational repositioning approaches have gained attraction for identifying potential drug-disease associations (DDAs). Biologi...
BMC medical informatics and decision making
Jul 8, 2025
BACKGROUND: Anaemia is a common complication after kidney transplantation, and the haemoglobin concentration is one of the main criteria for identifying anaemia. Moreover, artificial intelligence methods have developed rapidly in recent years, are wi...
Cell communication and signaling : CCS
Jul 8, 2025
Characterized by high malignancy and limited treatment efficacy, triple-negative breast cancer (TNBC) remains a clinically challenging subtype within breast cancer classifications, marked by rapid progression and high mortality. Abnormal activation o...
BMC medical informatics and decision making
Jul 8, 2025
BACKGROUND: Developing medical software requires navigating complex regulatory, ethical, and operational challenges. A comprehensive framework that supports both technical maturity and clinical safety is essential for effective artificial intelligenc...
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