AIMC Topic: Humans

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Robot-assisted tremor control for performance enhancement of retinal microsurgeons.

The British journal of ophthalmology Dec 20, 2018
Pars plana vitrectomy is a challenging, minimally invasive microsurgical procedure due to its intrinsic manoeuvres and physiological limits that constrain human capability. An important human limitation is physiological hand tremor, which can signifi...
Tremor Microsurgery Vitrectomy Ophthalmologists Humans Robotics
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Analysis of intensity normalization for optimal segmentation performance of a fully convolutional neural network.

Zeitschrift fur medizinische Physik Dec 20, 2018
INTRODUCTION: Convolutional neural networks have begun to surpass classical statistical- and atlas based machine learning techniques in medical image segmentation in recent years, proving to be superior in performance and speed. However, a major chal...
Image Processing, Computer-Assisted Magnetic Resonance Imaging Humans Neural Networks, Computer
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From Machine to Machine: An OCT-Trained Deep Learning Algorithm for Objective Quantification of Glaucomatous Damage in Fundus Photographs.

Ophthalmology Dec 20, 2018
PURPOSE: Previous approaches using deep learning (DL) algorithms to classify glaucomatous damage on fundus photographs have been limited by the requirement for human labeling of a reference training set. We propose a new approach using quantitative s...
ROC Curve Visual Acuity Tomography, Optical Coherence Male Middle Aged Deep Learning Retinal Ganglion Cells Visual Fields Visual Field Tests Fundus Oculi Nerve Fibers Optic Disk Algorithms Female Aged Aged, 80 and over Cross-Sectional Studies Intraocular Pressure Humans Tonometry, Ocular Gonioscopy Optic Nerve Diseases Photography Glaucoma, Open-Angle
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Retrospective Data Analysis of the Influence of Age and Sex on TPMT Activity and Its Phenotype-Genotype Correlation.

The journal of applied laboratory medicine Dec 20, 2018
BACKGROUND: Therapeutic efficacy and toxicity of thiopurine drugs (used as anticancer and immunosuppressant agents) are affected by thiopurine S-methyltransferase (TPMT) enzyme activity. genotype and/or phenotype is used to predict the risk for adve...
Sex Factors Gene Frequency Adult Methyltransferases Male Female Age Factors Humans Middle Aged Chromatography, Liquid Aged Data Analysis Adolescent Tandem Mass Spectrometry Young Adult Retrospective Studies Genetic Association Studies Inflammation
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Broadening the Perspective of Cost-Effectiveness Modeling in Chronic Obstructive Pulmonary Disease: A New Patient-Level Simulation Model Suitable to Evaluate Stratified Medicine.

Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research Dec 20, 2018
OBJECTIVES: To develop a health economic model that included a great diversity of patient characteristics and outcomes for chronic obstructive pulmonary disease (COPD), which can be used to inform decisions about stratified medicine in COPD.
Cost-Benefit Analysis Models, Economic Pulmonary Disease, Chronic Obstructive Quality-Adjusted Life Years Humans Male Computer Simulation Middle Aged Female
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Automated beat-wise arrhythmia diagnosis using modified U-net on extended electrocardiographic recordings with heterogeneous arrhythmia types.

Computers in biology and medicine Dec 20, 2018
Abnormality of the cardiac conduction system can induce arrhythmia - abnormal heart rhythm - that can frequently lead to other cardiac diseases and complications, and are sometimes life-threatening. These conduction system perturbations can manifest ...
Female Male Electrocardiography Signal Processing, Computer-Assisted Arrhythmias, Cardiac Humans Neural Networks, Computer Databases, Factual
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MILD-Net: Minimal information loss dilated network for gland instance segmentation in colon histology images.

Medical image analysis Dec 20, 2018
The analysis of glandular morphology within colon histopathology images is an important step in determining the grade of colon cancer. Despite the importance of this task, manual segmentation is laborious, time-consuming and can suffer from subjectiv...
Humans Image Processing, Computer-Assisted Software Histological Techniques Adenocarcinoma Colorectal Neoplasms Automation Deep Learning
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Automated diagnosis of breast ultrasonography images using deep neural networks.

Medical image analysis Dec 20, 2018
Ultrasonography images of breast mass aid in the detection and diagnosis of breast cancer. Manually analyzing ultrasonography images is time-consuming, exhausting and subjective. Automated analyzing such images is desired. In this study, we develop a...
Image Interpretation, Computer-Assisted Female Humans Breast Neoplasms Neural Networks, Computer Ultrasonography, Mammary
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Biodegradable Thermomagnetically Responsive Soft Untethered Grippers.

ACS applied materials & interfaces Dec 20, 2018
Soft-robotic devices such as polymeric microgrippers offer the possibility for pick and place of fragile biological cargo in hard-to-reach conduits with potential applications in drug delivery, minimally invasive surgery, and biomedical engineering. ...
Humans Drug Delivery Systems Hydrogels Methacrylates Magnetic Fields Cell Line, Transformed Robotics Magnetite Nanoparticles Acrylic Resins
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Deep learning enables de novo peptide sequencing from data-independent-acquisition mass spectrometry.

Nature methods Dec 20, 2018
We present DeepNovo-DIA, a de novo peptide-sequencing method for data-independent acquisition (DIA) mass spectrometry data. We use neural networks to capture precursor and fragment ions across m/z, retention-time, and intensity dimensions. They are t...
Peptides Deep Learning Mass Spectrometry Databases, Protein Humans
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