AIMC Topic: Lipid Metabolism
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Machine learning-based algorithm identifies key mitochondria-related genes in non-alcoholic steatohepatitis.
Lipids in health and disease
May 8, 2024
BACKGROUND: Evidence suggests that hepatocyte mitochondrial dysfunction leads to abnormal lipid metabolism, redox imbalance, and programmed cell death, driving the onset and progression of non-alcoholic steatohepatitis (NASH). Identifying hub mitocho...
Identification of biomarkers and immune infiltration characterization of lipid metabolism-associated genes in osteoarthritis based on machine learning algorithms.
Aging
Apr 17, 2024
Osteoarthritis (OA) is a prevalent degenerative condition commonly observed in the elderly, leading to consequential disability. Despite notable advancements made in clinical strategies for OA, its pathogenesis remains uncertain. The intricate associ...
Recent advances in label-free imaging and quantification techniques for the study of lipid droplets in cells.
Current opinion in cell biology
Feb 29, 2024
Lipid droplets (LDs), once considered mere storage depots for lipids, have gained recognition for their intricate roles in cellular processes, including metabolism, membrane trafficking, and disease states like obesity and cancer. This review explore...
Multimodal deep learning as a next challenge in nutrition research: tailoring fermented dairy products based on -mediated lipid metabolism.
Critical reviews in food science and nutrition
Aug 24, 2023
Deep learning is evolving in nutritional epidemiology to address challenges including precise nutrition and data-driven disease modeling. Fermented dairy products consumption as the implementation of specific dietary priority contributes to a lower r...
The antidiabetic drug pioglitazone ameliorates betel-nut-induced carcinogenesis in mice by restoring normal lipid metabolism, reducing oxidative stress, and inducing apoptosis.
Journal of cancer research and therapeutics
Apr 27, 2023
CONTEXT: Oral administration (2 mg mL-1) of aqueous extract of betel nut (AEBN) for 24 weeks induced oncogenic alterations in the liver of female Swiss Albino mice concomitant with aberrant lipid metabolism, overactivation of Akt/mTOR signaling, and ...
Exposure to nitrate induces alterations in blood parameter responses, liver immunity, and lipid metabolism in juvenile turbot (Scophthalmus maximus).
Aquatic toxicology (Amsterdam, Netherlands)
Aug 24, 2022
Nitrate (NO) pollution of waterbodies has attracted significant global attention as it poses a serious threat to aquatic organisms and human beings. This study aimed to evaluate the role of NO, an end product of biological nitrification processes, in...
Lipid Metabolism
Heat-Shock Proteins
Nitrates
Alanine Transaminase
Animals
Liver X Receptors
Complement C3
Aspartate Aminotransferases
RNA, Messenger
Humans
Carnitine O-Palmitoyltransferase
Muramidase
Fish Proteins
Water Pollutants, Chemical
Immunoglobulin M
Tumor Necrosis Factor-alpha
Peroxisome Proliferator-Activated Receptors
Sterol Regulatory Element Binding Protein 1
Liver
Flatfishes
Complement C4
The Anti-Adiposity Mechanisms of Ampelopsin and Vine Tea Extract in High Fat Diet and Alcohol-Induced Fatty Liver Mouse Models.
Molecules (Basel, Switzerland)
Jan 18, 2022
(AG) is an ancient medicinal plant that is mainly distributed and used in southwest China. It exerts therapeutic effects, such as antioxidant, anti-diabetic, and anti-inflammatory activities, reductions in blood pressure and cholesterol and hepatopr...
Risk stratification of ST-segment elevation myocardial infarction (STEMI) patients using machine learning based on lipid profiles.
Lipids in health and disease
May 6, 2021
BACKGROUND: Numerous studies have revealed the relationship between lipid expression and increased cardiovascular risk in ST-segment elevation myocardial infarction (STEMI) patients. Nevertheless, few investigations have focused on the risk stratific...
Humans
Prognosis
Female
Aged
Principal Component Analysis
ST Elevation Myocardial Infarction
Apolipoprotein A-I
Percutaneous Coronary Intervention
Cholesterol, LDL
Male
Middle Aged
Risk Assessment
Unsupervised Machine Learning
Triglycerides
Lipid Metabolism
Kaplan-Meier Estimate
Patient Selection
Apolipoprotein B-100
Patient Readmission
Lipoprotein(a)
Cholesterol, HDL
Evidence of vascular endothelial dysfunction in Wooden Breast disorder in chickens: Insights through gene expression analysis, ultra-structural evaluation and supervised machine learning methods.
PloS one
Jan 4, 2021
Several gene expression studies have been previously conducted to characterize molecular basis of Wooden Breast myopathy in commercial broiler chickens. These studies have generally used a limited sample size and relied on a binary disease outcome (u...
Machine learning of human plasma lipidomes for obesity estimation in a large population cohort.
PLoS biology
Oct 18, 2019
Obesity is associated with changes in the plasma lipids. Although simple lipid quantification is routinely used, plasma lipids are rarely investigated at the level of individual molecules. We aimed at predicting different measures of obesity based on...
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