Journal of chemical information and modeling
Sep 4, 2025
Lipids are essential metabolites that play critical roles in multiple cellular pathways. Like many primary metabolites, mutations that disrupt lipid synthesis can be lethal. Proteins involved in lipid synthesis, trafficking, and modification, are tar...
Lipidomic profiling generates vast datasets, making manual annotation and trend interpretation complex and time-intensive. The structural and chemical diversity of the lipidome further complicates the analysis. While existing tools support targeted l...
Journal of controlled release : official journal of the Controlled Release Society
Aug 28, 2025
Adipose tissue plays a crucial role in energy metabolism and endocrine signaling. White adipose tissue (WAT), in particular, is a compelling target for therapeutic interventions in metabolic diseases due to its secretory capacity and abundance. Gene ...
International journal of pharmaceutics
Aug 24, 2025
PURPOSE: The development of a novel lipid-based formulation for apalutamide, a potent androgen receptor inhibitor for non-metastatic castration-resistant prostate cancer (nmCRPC), is explored in this study.
Identifying carbon-carbon double bond (C=C) positions in complex lipids is essential for elucidating physiological and pathological processes. Currently, this is impossible in high-throughput analyses of native lipids without specialized instrumentat...
Niemann-Pick type C (NPC) disease is a devastating, fatal, neurodegenerative disease and a form of lysosomal storage disorder. It is caused by mutations in either NPC1 or NPC2 genes, leading to the accumulation of cholesterol and other lipids in the ...
Mathematical models are conventionally used to understand the of tumor behaviors, but they generally lack in precisely correlating drug efficacy with tumor response. Artificial intelligence (AI) has forged a new avenue in cancer management, but requi...
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
Jul 10, 2025
This study investigates the potential of Raman spectroscopy in distinguishing between healthy individuals and prostate cancer patients using urine samples. The Boruta algorithm was applied to Raman spectral data in two distinct wavenumber regions: 80...
This review explores the application of lipidomics in livestock and poultry meat research, focusing on lipid identification and analysis from the perspectives of meat quality and flavor. We offer a comprehensive overview of lipid extraction methods a...
BACKGROUNDObesity, a growing health concern, often leads to metabolic disturbances, systemic inflammation, and vascular dysfunction. Emerging evidence suggests that adipose tissue-derived extracellular vesicles (adiposomes) may propagate obesity-rela...
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