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Liver Transplantation

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Integrated Bioinformatics and Validation Reveal and Its Related Molecules as Potential Identifying Genes in Liver Cirrhosis.

Biomolecules
Liver cirrhosis remains a significant global public health concern, with liver transplantation standing as the foremost effective treatment currently available. Therefore, investigating the pathogenesis of liver cirrhosis and developing novel therapi...

3D auto-segmentation of biliary structure of living liver donors using magnetic resonance cholangiopancreatography for enhanced preoperative planning.

International journal of surgery (London, England)
BACKGROUND: This study aimed to develop an automated segmentation system for biliary structures using a deep learning model, based on data from magnetic resonance cholangiopancreatography (MRCP).

Impact of an artificial intelligence based model to predict non-transplantable recurrence among patients with hepatocellular carcinoma.

HPB : the official journal of the International Hepato Pancreato Biliary Association
OBJECTIVE: We sought to develop Artificial Intelligence (AI) based models to predict non-transplantable recurrence (NTR) of hepatocellular carcinoma (HCC) following hepatic resection (HR).

Why your doctor is not an algorithm: Exploring logical principles of different clinical inference methods using liver transplantation as a model.

Gastroenterologia y hepatologia
The development of machine learning (ML) tools in many different medical settings is largely increasing. However, the use of the resulting algorithms in daily medical practice is still an unsolved challenge. We propose an epistemological approach (i....

Deep learning-based pathway-centric approach to characterize recurrent hepatocellular carcinoma after liver transplantation.

Human genomics
BACKGROUND: Liver transplantation (LT) is offered as a cure for Hepatocellular carcinoma (HCC), however 15-20% develop recurrence post-transplant which tends to be aggressive. In this study, we examined the transcriptome profiles of patients with rec...

Machine-learning model to predict the tacrolimus concentration and suggest optimal dose in liver transplantation recipients: a multicenter retrospective cohort study.

Scientific reports
Titrating tacrolimus concentration in liver transplantation recipients remains a challenge in the early post-transplant period. This multicenter retrospective cohort study aimed to develop and validate a machine-learning algorithm to predict tacrolim...

Artificial intelligence-based model for the recurrence of hepatocellular carcinoma after liver transplantation.

Surgery
BACKGROUND: Artificial intelligence-based models might improve patient selection for liver transplantation in hepatocellular carcinoma. The objective of the current study was to develop artificial intelligence-based deep learning models and determine...

Real-time segmentation of biliary structure in pure laparoscopic donor hepatectomy.

Scientific reports
Pure laparoscopic donor hepatectomy (PLDH) has become a standard practice for living donor liver transplantation in expert centers. Accurate understanding of biliary structures is crucial during PLDH to minimize the risk of complications. This study ...