BACKGROUND: Lung cancer is a leading cause of cancer-related mortality worldwide. Accurate staging of mediastinal lymph nodes is a crucial step in determining appropriate treatment approaches. Current noninvasive diagnostic methods do not provide suf...
OBJECTIVES: Respiratory motion poses a significant challenge for clinical workflows in diagnostic imaging and radiation therapy. Many technologies such as motion artifact reduction and tumor tracking have been developed to compensate for its effect. ...
PURPOSE: The precise contouring of gross tumor volume lymph nodes (GTVnd) is an essential step in clinical target volume delineation. This study aims to propose and evaluate a deep learning model for segmenting GTVnd specifically in lung cancer, repr...
BACKGROUND: In the era of data and intelligence, artificial intelligence has been widely applied in the medical field. As the most cutting-edge technology, the large language model (LLM) has gained popularity due to its extraordinary ability to handl...
BACKGROUND: With nearly one-third of patients with advanced non-small cell lung cancer (NSCLC) and PD-L1 Tumor Proportion Score≥50% surviving beyond 5 years following first-line pembrolizumab, long-term outcomes challenge traditional paradigms of can...
Characterizing and validating which mutations influence development of cancer is challenging. Artificial intelligence (AI) has delivered significant advances in protein structure prediction, but its utility for identifying cancer drivers is less expl...
OBJECTIVE: To develop a predictive framework integrating machine learning and clinical parameters for postoperative pulmonary complications (PPCs) in non-small cell lung cancer (NSCLC) patients undergoing video-assisted thoracic surgery (VATS).
BACKGROUND: Immunogenic cell death (ICD) triggers antitumor immune responses and plays a critical role in shaping the tumor microenvironment (TME). However, its specific contribution to lung adenocarcinoma (LUAD) progression and immunotherapy respons...
Exosomes are critical biomarkers for early cancer diagnosis and prognosis due to their rich biological information. Nevertheless, analyzing exosomal biomarkers comprehensively remains challenging. Surface-enhanced Raman scattering (SERS) has been emp...
Deciphering the pre-malignant cell of origin (COO) of different cancers is critical for understanding tumor development and improving diagnostic and therapeutic strategies in oncology. Prior work demonstrates that somatic mutations preferentially acc...
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