This study investigates the shared molecular mechanisms between major depressive disorder (MDD) and systemic lupus erythematosus (SLE) through integrated bioinformatics analysis. Analysis of multiple GEO datasets identified 23 common differentially e...
Systemic lupus erythematosus (SLE), characterized by immune dysregulation, urgently requires improved diagnostic tools and mechanistic insights. The role of interferon regulatory factor-1 (IRF-1) remains unclear. We integrated single-cell transcripto...
Individuals with both Lupus Erythematosus and pre-existing heart conditions are more likely to develop severe symptoms, emphasizing the complex and not fully understood interaction between the disease and cardiovascular health. A universal diagnostic...
BACKGROUND: Systemic lupus erythematosus (SLE) is a life-threatening, multisystem autoimmune disease. Biologic therapy is a promising treatment for SLE. However, public understanding of this therapy is still insufficient, and the quality of related i...
BACKGROUND: Systemic lupus erythematosus (SLE) is a chronic disease characterized by a broad spectrum of involved organs, including neurological, renal, and vascular domains, with disease activity manifesting through unpredictable patterns that vary ...
Systemic Lupus Erythematosus (SLE) is a chronic, autoimmune disease characterized by multiple organ involvement and autoantibodies, and its diagnosis is not easy in clinical practice. Pediatric SLE (pSLE) is diagnosed using the SLICC 2012 criteria fo...
Evidence indicates a connection between periodontitis (PD) and systemic lupus erythematosus (SLE), though the underlying co-morbid mechanisms remain unclear. This study sought to identify the genetic factors and potential therapeutic agents involved ...
OBJECTIVE: SLE is a chronic autoimmune disease with immune complex deposition in various organs, causing inflammation. The Systemic Lupus Erythematosus Disease Activity Index 2000 assesses disease severity but is subjective. This study aimed to const...
BACKGROUND: Systemic lupus erythematosus (SLE) is a complex autoimmune disease that has significant impacts on patients' quality of life and poses a substantial economic burden on society.
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