AIMC Topic: Lysine
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Predicting lysine-malonylation sites of proteins using sequence and predicted structural features.
Journal of computational chemistry
May 14, 2018
Malonylation is a recently discovered post-translational modification (PTM) in which a malonyl group attaches to a lysine (K) amino acid residue of a protein. In this work, a novel machine learning model, SPRINT-Mal, is developed to predict malonylat...
Prediction of lysine glutarylation sites by maximum relevance minimum redundancy feature selection.
Analytical biochemistry
Apr 8, 2018
Lysine glutarylation is new type of protein acylation modification in both prokaryotes and eukaryotes. To better understand the molecular mechanism of glutarylation, it is important to identify glutarylated substrates and their corresponding glutaryl...
New insights into the efficiency of thymol synergistic effect with p-cymene in inhibiting advanced glycation end products: A multi-way analysis based on spectroscopic and electrochemical methods in combination with molecular docking study.
Journal of pharmaceutical and biomedical analysis
Dec 24, 2017
Protein glycation in the body is one of the main reasons of diabetes complications. The electrochemical studies on the inhibitory mechanism of glycation are rather scarce. Thus, it is important to investigate the role of electrochemistry in the glyca...
Molecular Docking Simulation
Protein Binding
Glycosylation
Hypoglycemic Agents
Spectrophotometry, Ultraviolet
Protein Processing, Post-Translational
Cymenes
Structure-Activity Relationship
Thymol
Protein Conformation
Electrochemical Techniques
Binding Sites
Drug Synergism
Kinetics
Lysine
Monoterpenes
Arginine
Serum Albumin, Bovine
Glycation End Products, Advanced
The Major Chromophore Arising from Glucose Degradation and Oxidative Stress Occurrence during Lens Proteins Glycation Induced by Glucose.
Molecules (Basel, Switzerland)
Dec 22, 2017
Glucose autoxidation has been proposed as a key reaction associated with deleterious effects induced by hyperglycemia in the eye lens. Little is known about chromophores generated during glucose autoxidation. In this study, we analyzed the effect of ...
l-Carnosine supplementation attenuated fasting glucose, triglycerides, advanced glycation end products, and tumor necrosis factor-α levels in patients with type 2 diabetes: a double-blind placebo-controlled randomized clinical trial.
Nutrition research (New York, N.Y.)
Nov 17, 2017
Considering the pathologic importance of metabolic disturbances, advanced glycation end products (AGEs), and chronic inflammation in diabetes mellitus and ameliorating potentials of l-carnosine in hampering these detritions and because these effects ...
Glypre: In Silico Prediction of Protein Glycation Sites by Fusing Multiple Features and Support Vector Machine.
Molecules (Basel, Switzerland)
Nov 3, 2017
Glycation is a non-enzymatic process occurring inside or outside the host body by attaching a sugar molecule to a protein or lipid molecule. It is an important form of post-translational modification (PTM), which impairs the function and changes the ...
Predicting lysine glycation sites using bi-profile bayes feature extraction.
Computational biology and chemistry
Oct 12, 2017
Glycation is a nonenzymatic post-translational modification which has been found to be involved in various biological processes and closely associated with many metabolic diseases. The accurate identification of glycation sites is important to unders...
Enhanced d-tagatose production by spore surface-displayed l-arabinose isomerase from isolated Lactobacillus brevis PC16 and biotransformation.
Bioresource technology
Oct 3, 2017
In the present study, a new strain of Lactobacillus brevis producing d-tagatose was isolated and identified. Then, the l-arabinose isomerase (L-AI) of this strain was displayed on the spore surface of Bacillus subtilis DB403 by using an anchoring pro...
Prediction of CML contents in the Maillard reaction products for casein-monosaccharides model.
Food chemistry
Jul 27, 2017
Response surface methodology (RSM) was applied to predict the processing parameters of the casein-glucose/galactose Maillard reaction (MR) for determining the level of N-(1-carboxymethyl)-l-lysine (CML), one of the typically harmful dietary advanced ...
Prediction of lysine propionylation sites using biased SVM and incorporating four different sequence features into Chou's PseAAC.
Journal of molecular graphics & modelling
Jul 25, 2017
Lysine propionylation is an important and common protein acylation modification in both prokaryotes and eukaryotes. To better understand the molecular mechanism of propionylation, it is important to identify propionylated substrates and their corresp...
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