International journal of pharmaceutics
Aug 16, 2025
This study aimed to explore the potential of a Machine learning (ML)-integrated Quality by design (QbD) process to formulate resveratrol (RES)-loaded polymeric nanoparticles (RES-PNPs) for potential use in transdermal drug delivery. The RES-PNPs were...
Journal of controlled release : official journal of the Controlled Release Society
Aug 16, 2025
Amorphous solid dispersions (ASDs) have emerged as a pivotal strategy in enhancing the dissolution profiles of poorly water-soluble drugs. Although the apparent dissolution rate (both molecular and colloidal drugs) within ASDs has been determined in ...
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
Aug 15, 2025
Diabetic encephalopathy is a progressive complication of type 2 diabetes, yet its region-specific biochemical changes remain unclear. In this study, we applied Fourier Transform Infrared Microspectroscopy (FTIRM) to assess metabolic alterations in th...
BACKGROUND: This study aims to apply a semi-supervised machine learning approach for classifying major depressive disorder (MDD) patients into more homogeneous cognitive subtypes based on multidimensional cognitive profiles, and to perform multimodal...
International journal of food microbiology
Aug 15, 2025
This study presents a comprehensive investigation of Escherichia coli O157:H7 survival and transfer on six cold chain packaging materials through experimental characterization and machine learning modeling. Survival experiments revealed significant m...
The American journal of sports medicine
Aug 15, 2025
BACKGROUND: Treatment decisions in patients with anterior cruciate ligament (ACL) injuries are influenced by multiple factors, such as the desire to return to sports or symptomatic instability. Identifying the differential treatment effect of ACL rec...
Journal of chemical information and modeling
Aug 15, 2025
Cyclic sulfamidates are commonly used building blocks in organic synthesis. Correct classification of their thermal criticality is crucial for the safe use of these compounds in process development and scale-up. In this study, building on our earlier...
Applied and environmental microbiology
Aug 14, 2025
comprise ecologically significant bacteria that thrive in warm, moderately saline water, and their incidence and proliferation are strongly influenced by environmental factors. In recent years, . infections have been reported more frequently and ove...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to accumulate mutations in the spike receptor-binding domain (RBD) region, leading to the emergence of new variants that potentially change the binding affinity for the human angi...
Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society
Aug 14, 2025
Joint machine learning models that allow synthesizing and classifying data often offer uneven performance between those tasks or are unstable to train. In this work, we depart from a set of empirical observations that indicate the usefulness of inter...
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