Journal of computer-aided molecular design
Jul 16, 2025
Alzheimer's disease (AD) is a progressive neurodegenerative disorder lacking effective therapies. Glycogen synthase kinase-3β (GSK-3β), a key regulator of Aβ aggregation and Tau hyperphosphorylation, has emerged as a promising therapeutic target. Her...
This study aims to improve predictions and understanding of dissolved organic carbon-water partitioning coefficients (), a crucial parameter in environmental risk assessment. A dataset encompassing 709 datapoints across 190 unique organic pollutants ...
Electronic payment methods are increasingly prevalent worldwide, facilitating both in-person and online transactions. As credit card usage for online payments grows, fraud and payment defaults have also risen, resulting in significant financial losse...
BACKGROUND: Sepsis-associated delirium (SAD) occurs due to disruptions in neurotransmission linked to inflammatory responses from infections. It poses significant challenges in clinical management and is associated with poor outcomes. Survivors often...
The evaluation of rice varieties is a complex, time-consuming process requiring advanced equipment. This study aimed to discriminate 22 commercial rice varieties from six types by analyzing biochemical, physicochemical, and cooking properties. Near-i...
Immunotherapy has become a cornerstone in the treatment of advanced gastric cancer (GC). However, identifying reliable predictive biomarkers remains a considerable challenge. This study demonstrates the potential of integrating multimodal baseline da...
Clinica chimica acta; international journal of clinical chemistry
Jul 15, 2025
OBJECTIVE: Immunoglobulin D (IgD) myeloma is a rare subtype of multiple myeloma (MM), comprising approximately 1 %-2 % of all MM cases. Owing to the diminished levels of IgD in serum, IgD MM manifests as subtle M protein spikes in routine serum elect...
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
Jul 15, 2025
BACKGROUND: Survival of patients with high-risk hepatoblastoma remains low, and early identification of high-risk hepatoblastoma is critical.
We aimed to explore the metabolic dysregulations and diagnostic biomarkers for post-traumatic deep venous thrombosis (pt-DVT) in hypertensive (HPT) patients after fracture. An untargeted ultraperformance liquid chromatography-mass spectrometry-based ...
Methicillin-resistant (MRSA) is a major cause of healthcare-associated infections including bacteremia. The rapid detection of MRSA is essential for prompt treatment and improved outcomes. However, traditional MRSA screening and confirmatory tests b...
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