This study highlights the importance of evaluating warfarin dosing in diabetic patients, who require careful anticoagulation management. With rising rates of diabetes and cardiovascular diseases, understanding the factors influencing warfarin therapy...
The aggregation of α-synuclein is crucial to the development of Lewy body diseases, including Parkinson's disease and dementia with Lewy bodies. The aggregation pathway of α-synuclein typically involves a defined sequence of nucleation, elongation, a...
Journal of chemical information and modeling
Jan 28, 2025
In the field of computational chemistry, predicting bond dissociation energies (BDEs) presents well-known challenges, particularly due to the multireference character of reactive systems. Many chemical reactions involve configurations where single-re...
Current opinion in structural biology
Jan 28, 2025
Recent progress and development of artificial intelligence and machine learning (AI/ML) techniques have enabled addressing complex biomolecular problems. AI/ML models learn the underlying distribution of data they are trained on and when exposed to n...
Developing affordable, rapid, and accurate biosensors is essential for SARS-CoV-2 surveillance and early detection. We created a bio-inspired peptide, using the SAGAPEP AI platform, for COVID-19 salivary diagnostics via a portable electrochemical dev...
In experimental research, animal welfare should always be of the highest priority. Currently, physical in-person observations are the standard. This is time-consuming, and results are subjective. Video-based machine learning models for monitoring exp...
International journal of molecular sciences
Jan 28, 2025
Antimicrobial resistance (AMR) is one of the most pressing public health challenges of the 21st century. This study aims to evaluate the efficacy of mass spectral data generated by VITEK MS instruments for predicting antibiotic resistance in , , and ...
BACKGROUND: Alzheimer's disease (AD), a hallmark of age-related cognitive decline, is defined by its unique neuropathology. Metabolic dysregulation, particularly involving glutamine (Gln) metabolism, has emerged as a critical but underexplored aspect...
BACKGROUND: With the rising diagnostic rate of gallbladder polypoid lesions (GPLs), differentiating benign cholesterol polyps from gallbladder adenomas with a higher preoperative malignancy risk is crucial. This study aimed to establish a preoperativ...
BACKGROUND: High-throughput behavioral analysis is important for drug discovery, toxicological studies, and the modeling of neurological disorders such as autism and epilepsy. Zebrafish embryos and larvae are ideal for such applications because they ...
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