Echocardiographic left ventricular hypertrophy (Echo-LVH) is frequently underdetected by traditional electrocardiogram (ECG) criteria due to limited sensitivity. We investigated whether integrating ECG with vectorcardiography (VCG) using a clinically...
In the context of global climate change, this study aims to investigate the spatial heterogeneity and driving mechanisms of the urban heat island (UHI) effect within Xi'an's second ring road area. We constructed a novel multi-source data fusion frame...
BACKGROUND: Depression exhibits significant heterogeneity in antidepressant treatment response. This study aimed to develop an Electroencephalography (EEG)-based machine learning model integrating multidimensional features to predict selective seroto...
The objective of this study was to identify chemical constituents as markers of six per- and polyfluoroalkyl substance (PFAS) sources including aqueous film-forming foam-impacted groundwater, landfill leachate, biosolids leachate, municipal wastewate...
Dual-omics, by integrating molecular information from two distinct dimensions, can offer more comprehensive perspective for complex disease. Herein, we developed an efficient functionalized mesoporous nanoparticle-coupled laser desorption/ionization ...
Journal of chemical information and modeling
Oct 16, 2025
The analysis and prediction of antibody-antigen (Ab-Ag) interactions often overlook critical structural features such as glycosylation and important physicochemical conditions like pH and salt concentration. Additionally, the field lacks standardized...
Journal of chemical information and modeling
Oct 16, 2025
Light-driven molecular nanomotors hold promise for applications in materials science and biomedicine. Significant efforts have focused on improving their efficiency, often targeting single candidate molecules. Here, we present a systematic, data-driv...
Proceedings of the National Academy of Sciences of the United States of America
Oct 16, 2025
T cells play a key role in adaptive immunity by mounting specific responses against diverse pathogens. Effective bindings between T cell receptors (TCRs) and pathogen derived peptides presented on major histocompatibility complexes (MHCs) mediate imm...
BACKGROUND: Sepsis is a severe and frequent complication among ischemic stroke patients during hospitalization. The atherogenic index of plasma (AIP), as metabolism-related markers, are closely linked to inflammation. However, their relationship with...
Neurological impairments resulting from bilirubin encephalopathy represent a hallmark of bilirubin's neurotoxic effects. Earlier research suggests that bilirubin may contribute to Alzheimer's disease (AD) pathology by inducing neuronal necrosis and a...
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