Cancer immunology, immunotherapy : CII
Nov 18, 2025
Immunohistochemistry (IHC) remains the gold standard for evaluating protein expression in tumor microenvironment analysis. This approach hinders robust correlation analyses between spatial heterogeneity in the tumor microenvironment and clinical outc...
This study examines the function of chromatin-remodeling genes (CRGs) in nasopharyngeal carcinoma (NPC), with an emphasis on their potential as prognostic and diagnostic biomarkers. We examined gene expression information collected from multiple data...
Patients with early-onset kidney cancer (EOKC) face a marked decline in prognosis after distant metastasis, yet the accuracy of current predictive methods remains limited. This study aims to develop a predictive model using multiple machine learning ...
Journal of neurointerventional surgery
Nov 18, 2025
BACKGROUND: We investigate the association of imaging biomarkers extracted from fully automated body composition analysis (BCA) of computed tomography (CT) angiography images of endovascularly treated acute ischemic stroke (AIS) patients regarding an...
Journal of controlled release : official journal of the Controlled Release Society
Nov 17, 2025
Long-acting injectables (LAIs) represent promising drug delivery platforms for chronic diseases management, but their clinical translation remains constrained by extremely long trial-and-error experiments (8-10 years), limited mechanism insights, and...
ST-elevation myocardial infarction (STEMI) remains a leading cause of cardiovascular morbidity and mortality worldwide, and accurate early risk stratification is critical for implementing precision therapies in clinical practice. However, existing cl...
BACKGROUND: Three-vessel coronary artery disease (TVD) is a severe subtype of coronary heart disease, strongly associated with inflammation and metabolic dysfunction. The C-reactive protein-triglyceride glucose index (CTI), an integrated measure of i...
The European journal of general practice
Nov 17, 2025
BACKGROUND: Healthcare demand in English general practice exceeds supply, necessitating practice efficiency. To our knowledge, no study has explored factors associated with practice efficiency in England using a quality-adjusted output.
BACKGROUND: This study sought to identify critical body composition characteristics associated with surgical difficulty in Laparoscopic Total Mesorectal Excision (LaTME) and to develop and validate an interpretable machine learning model using body c...
Journal of neuroengineering and rehabilitation
Nov 17, 2025
BACKGROUND: This study aimed to evaluate the effects of an end-effector-type upper-limb robot-assisted therapy (UL-RAT) combined with pneumatic gloves (PGs) on improving upper limb function in young and middle-aged stroke patients.
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