Automatic characterization of fluorescent labeling in intact mammalian tissues remains a challenge due to the lack of quantifying techniques capable of segregating densely packed nuclei and intricate tissue patterns. Here, we describe a powerful deep...
DNA methylation dynamics emerged as a promising biomarker of mammalian aging, with multivariate machine learning models ('epigenetic clocks') enabling measurement of biological age in bulk tissue samples. However, intrinsically sparse and binarized m...
Fighting with the infection is one of the most challenging and costly burdens of the healthcare system. Several types of antibiotics and antibacterial agents have been designed and used in combating this dilemma. Nevertheless, the overuse of drugs an...
Silver nanoparticles (AgNPs) are a common antimicrobial additive for a variety of applications, including wound care. However, AgNPs often undergo dissolution resulting in release of silver ions, with subsequent toxicity to mammalian cells. The corne...
Our knowledge of viral host ranges remains limited. Completing this picture by identifying unknown hosts of known viruses is an important research aim that can help identify and mitigate zoonotic and animal-disease risks, such as spill-over from anim...
International journal of molecular sciences
Jan 22, 2021
One of the important questions in aging research is how differences in transcriptomics are associated with the longevity of various species. Unfortunately, at the level of individual genes, the links between expression in different organs and maximum...
In neuroscience, computational modeling is an effective way to gain insight into cortical mechanisms, yet the construction and analysis of large-scale network models-not to mention the extraction of underlying principles-are themselves challenging ta...
Diseases that spread to humans from animals, zoonoses, pose major threats to human health. Identifying animal reservoirs of zoonoses and predicting future outbreaks are increasingly important to human health and well-being and economic stability, par...
From small unicellular organisms to large mammals, swallowing is an important way for them to interact with their external environment. The majority of these animals swallow their targets for the purpose of hunting, and some fish and amphibians prote...
Advances in artificial intelligence are stimulating interest in neuroscience. However, most attention is given to discrete tasks with simple action spaces, such as board games and classic video games. Less discussed in neuroscience are parallel advan...