Nuclear Magnetic Resonance (NMR) spectroscopy is a powerful tool for analyzing complex mixtures due to its ability to manage matrix complexity, provide detailed molecular insights, and preserve sample integrity. In metabolomics, NMR enables the ident...
BACKGROUND: Newborn screening (NBS) enables early detection of metabolic disorders, but current tandem mass spectrometry (MS/MS) methods often lead to false positives and require confirmatory testing, causing diagnostic delays. We evaluated whether i...
OBJECTIVE: Anti-melanoma differentiation-associated gene 5-positive dermatomyositis (anti-MDA5 + DM) is a unique subtype of idiopathic inflammatory myopathy (IIM) with a poorer prognosis. The immune-metabolic landscape underlying anti-MDA5 + DM patho...
Metabolomics : Official journal of the Metabolomic Society
Nov 15, 2025
INTRODUCTION: Identifying the phytochemistry underpinning a plant's observed therapeutic benefits is essential for understanding mechanisms of action and developing novel therapeutics. More recent efforts fusing global metabolomics and multivariate p...
Metabolomics : Official journal of the Metabolomic Society
Nov 15, 2025
INTRODUCTION: Dementia can be prevented through early intervention; hence, there is an urgent need for biomarkers to help diagnose mild cognitive impairment (MCI).
BACKGROUND AND AIM: Gestational diabetes mellitus (GDM), a common pregnancy-related metabolic disorder, often goes undiagnosed until the second trimester, limiting early intervention opportunities. Given the higher prevalence of GDM in India, there i...
Journal of agricultural and food chemistry
Nov 12, 2025
Omics technologies are revolutionizing food and nutrition research by enabling high-throughput analysis of food components and microorganisms and revealing the intricate relationships between food and human health. Machine learning (ML) methods are p...
Immunotherapy has revolutionized hematologic cancer treatment, yet responses remain unpredictable due to primary resistance, relapse, and life-threatening toxicities. Conventional biomarkers fail to capture the complexity of tumor-immune interactions...
BACKGROUND: Sjögren's syndrome (SS) is a chronic autoimmune disorder marked by lymphocytic infiltration of exocrine glands, leading to xerostomia, keratoconjunctivitis sicca, and systemic involvement including fatigue, arthralgia, and visceral organ ...
BACKGROUND: Obesity is a disease with high heterogeneity. Both overall obesity and central obesity are associated with increased risks of having cardio-metabolic co-morbidities. This study is aimed to examine the cardio-metabolic characteristics and ...
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