Tauopathies are characterised by a progressive accumulation of hyperphosphorylated tau. However, early and intermediate stages remain challenging to quantify due to subtle and heterogeneous morphological characteristics. This study evaluates a deep l...
BACKGROUND: In the context of liver resection and transplantation, hepatic ischemia-reperfusion injury (hepatic IRI) remains a significant clinical challenge, profoundly impacting both postoperative short- and long-term recovery. A novel cell death p...
Proceedings of the National Academy of Sciences of the United States of America
Dec 26, 2025
Retinal ganglion cells (RGCs) transmit visual information from the eye to the brain. In mice, several RGC types show nonuniform spatial distributions, potentially mediating specific visual functions. However, the full extent of RGC specialization rem...
BACKGROUND: Atg9-containing vesicles are enriched in synapses and undergo cycles of exo- and endocytosis similarly to synaptic vesicles, thereby linking presynaptic autophagy to neuronal activity. Dysfunction of presynaptic autophagy is a pathophysio...
Proceedings of the National Academy of Sciences of the United States of America
Dec 10, 2025
Social information processing involves coordinated neural activity across distributed brain circuits, with the ventral hippocampus (vHPC) and medial prefrontal cortex (mPFC) playing pivotal roles. However, whether these regions employ distinct coding...
Neuronal ensemble activity, including coordinated and oscillatory patterns, exhibits hallmarks of nonequilibrium systems with time-asymmetric trajectories to maintain their organization. However, assessing time asymmetry from neuronal spiking activit...
The environmental pollutant Benzo[a]pyrene (B[a]P) and its ultimate metabolite B[a]P-7,8-diol-9,10-epoxide (BPDE) exhibit neurotoxic effects, yet the underlying molecular mechanisms remain enigmatic. Recently, ferroptosis has emerged as a potential p...
By transplanting pancreatic islets onto the dura mater of the mouse brain, we establish a microscopy platform that enables longitudinal intravital imaging of otherwise optically inaccessible tissue. The system combines a cranial window with an air-cu...
Liver fibrosis (LF) is a medical disorder caused by prolonged chronic liver injury, which, if left untreated, can progress to cirrhosis or liver cancer, posing significant risks to patient health. In recent years, the increase in liver diseases, incl...
Cytotoxic T cells (CD8) play a pivotal role in immunosurveillance by identifying and eliminating tumor cells. However, the onset of CD8 T cell exhaustion, characterized by overexpression of immune checkpoint receptors, impairs their function, allowin...
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