AIMC Topic: Mice

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A deep-learning approach for online cell identification and trace extraction in functional two-photon calcium imaging.

Nature communications Mar 22, 2022
In vivo two-photon calcium imaging is a powerful approach in neuroscience. However, processing two-photon calcium imaging data is computationally intensive and time-consuming, making online frame-by-frame analysis challenging. This is especially true...
Algorithms Animals Neural Networks, Computer Mice Calcium Deep Learning Image Processing, Computer-Assisted
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Deep-learning two-photon fiberscopy for video-rate brain imaging in freely-behaving mice.

Nature communications Mar 22, 2022
Scanning two-photon (2P) fiberscopes (also termed endomicroscopes) have the potential to transform our understanding of how discrete neural activity patterns result in distinct behaviors, as they are capable of high resolution, sub cellular imaging y...
Signal-To-Noise Ratio Brain Animals Mice Neuroimaging Deep Learning Algorithms
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Cell segmentation for immunofluorescence multiplexed images using two-stage domain adaptation and weakly labeled data for pre-training.

Scientific reports Mar 15, 2022
Cellular profiling with multiplexed immunofluorescence (MxIF) images can contribute to a more accurate patient stratification for immunotherapy. Accurate cell segmentation of the MxIF images is an essential step. We propose a deep learning pipeline t...
Animals Image Processing, Computer-Assisted Mice Neural Networks, Computer Software Staining and Labeling Fluorescent Antibody Technique Humans
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Deep learning tools and modeling to estimate the temporal expression of cell cycle proteins from 2D still images.

PLoS computational biology Mar 14, 2022
Automatic characterization of fluorescent labeling in intact mammalian tissues remains a challenge due to the lack of quantifying techniques capable of segregating densely packed nuclei and intricate tissue patterns. Here, we describe a powerful deep...
Animals Deep Learning Image Processing, Computer-Assisted Cell Nucleus Mice Cell Cycle Mammals Cell Cycle Proteins
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Automatic wound detection and size estimation using deep learning algorithms.

PLoS computational biology Mar 11, 2022
Evaluating and tracking wound size is a fundamental metric for the wound assessment process. Good location and size estimates can enable proper diagnosis and effective treatment. Traditionally, laboratory wound healing studies include a collection of...
Wound Healing Algorithms Animals Image Processing, Computer-Assisted Mice Deep Learning
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Identification of antimicrobial peptides from the human gut microbiome using deep learning.

Nature biotechnology Mar 3, 2022
The human gut microbiome encodes a large variety of antimicrobial peptides (AMPs), but the short lengths of AMPs pose a challenge for computational prediction. Here we combined multiple natural language processing neural network models, including LST...
Gastrointestinal Microbiome Anti-Bacterial Agents Animals Peptides Antimicrobial Peptides Adenosine Monophosphate Deep Learning Mice Humans
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An interactive framework for the detection of ictal and interictal activities: Cross-species and stand-alone implementation.

Computer methods and programs in biomedicine Mar 2, 2022
BACKGROUND AND OBJECTIVE: Despite advances on signal analysis and artificial intelligence, visual inspection is the gold standard in event detection on electroencephalographic recordings. This process requires much time of clinical experts on both an...
Mice Electroencephalography Seizures Epilepsy Artificial Intelligence Machine Learning Animals Humans
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Machine learning predicts cancer subtypes and progression from blood immune signatures.

PloS one Feb 28, 2022
Clinical adoption of immune checkpoint inhibitors in cancer management has highlighted the interconnection between carcinogenesis and the immune system. Immune cells are integral to the tumour microenvironment and can influence the outcome of therapi...
Myeloid Cells B7-H1 Antigen Machine Learning Colorectal Neoplasms Humans Tumor Microenvironment Disease Progression Mice Female Animals Cell Line, Tumor Mice, Inbred BALB C
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Anti-Fatigue and Exercise Performance Improvement Effect of Extract in Mice.

Nutrients Feb 27, 2022
(GT) is a native perennial plant growing across the coastline areas in Taiwan. The current study aimed to examine the efficacy of GT extract in ameliorating physical fatigue during exercise and increasing exercise performance. Fifty male Institute o...
Mice, Inbred ICR Mice Animals Asteraceae Plant Extracts Male Fatigue Physical Conditioning, Animal
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A deep learning-based toolbox for Automated Limb Motion Analysis (ALMA) in murine models of neurological disorders.

Communications biology Feb 15, 2022
In neuroscience research, the refined analysis of rodent locomotion is complex and cumbersome, and access to the technique is limited because of the necessity for expensive equipment. In this study, we implemented a new deep learning-based open-sourc...
Locomotion Spinal Cord Injuries Deep Learning Mice Disease Models, Animal Animals
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