Migraine is a complex neurological disorder with substantial heritability, yet genome-wide association studies (GWAS) have explained only a fraction of its genetic component. We developed InsightGWAS, a Transformer-based model, to enhance genetic dis...
PURPOSE: Separating BPV from other positional nystagmus types can be challenging. We examined the utility of nystagmus slow-phase velocity (SPV) profiles when seeking to separate canalithiasis benign positional vertigo (BPV) from its mimics.
BACKGROUND: Deep learning has demonstrated significant potential in advancing computer-aided diagnosis for neuropsychiatric disorders, such as migraine, enabling patient-specific diagnosis at an individual level. However, despite the superior accurac...
BACKGROUND: This study employed representative data from the U.S. and China to delve into the correlation among migraine prevalence, the triglyceride‒glucose index, a marker of insulin resistance, and the composite indicator of obesity.
Neurology(R) neuroimmunology & neuroinflammation
Jun 30, 2025
BACKGROUND AND OBJECTIVES: Emerging evidence suggests that oral health conditions may exacerbate migraine, and saliva is a potential source of biomarkers for migraine. The 3-way interaction of the oral-gut-brain axis has been implicated in several ne...
BACKGROUND: Genetic variations in the Trpm8 gene that encodes the cold receptor TRPM8 have been linked to protection against polygenic migraine, a disabling condition primarily affecting women. Noteworthy, TRPM8 has been recently found in brain areas...
BACKGROUND: Accumulating evidence suggests that migraine patients present abnormal brain responses to salient sensory and emotional stimuli. However, it is still unclear whether this is a generalized or domain-specific phenomenon. Employing a well-va...
Cephalalgia : an international journal of headache
Jun 12, 2025
BackgroundUnderstanding characteristics and reasons associated with using calcitonin gene-related peptide monoclonal antibodies (CGRP mAb) for migraine prevention may help clinicians individualize treatment plans and achieve better patient outcomes.M...
BACKGROUND: Migraine ranks as the second-leading cause of global neurological disability, affecting approximately 1.1Â billion individuals worldwide with severe quality-of-life impairments. Although adjustable risk factors-including environmental expo...
BACKGROUND: Migraine is associated with a range of symptoms and comorbid disorders and has a strong genetic basis, but the currently identified risk loci only explain a small portion of the heritability, often termed the "missing heritability". We ai...
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