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Molecular Epidemiology

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[Analysis on gene sequence of HIV isolated from men who have sex with men in Beijing].

Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi
OBJECTIVE: To analyze genetic characteristics of HIV isolated from men who have sex with men (MSM) in Beijing and predict the epidemic trend in this population.

Towards better prediction of Mycobacterium tuberculosis lineages from MIRU-VNTR data.

Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases
The determination of lineages from strain-based molecular genotyping information is an important problem in tuberculosis. Mycobacterial interspersed repetitive unit-variable number tandem repeat (MIRU-VNTR) typing is a commonly used molecular genotyp...

Statistical learning approaches in the genetic epidemiology of complex diseases.

Human genetics
In this paper, we give an overview of methodological issues related to the use of statistical learning approaches when analyzing high-dimensional genetic data. The focus is set on regression models and machine learning algorithms taking genetic varia...

Machine Learning Characterization of COPD Subtypes: Insights From the COPDGene Study.

Chest
COPD is a heterogeneous syndrome. Many COPD subtypes have been proposed, but there is not yet consensus on how many COPD subtypes there are and how they should be defined. The COPD Genetic Epidemiology Study (COPDGene), which has generated 10-year lo...

Machine learning reveals the dynamic importance of accessory sequences for outbreak clustering.

mBio
UNLABELLED: Bacterial typing at whole-genome scales is now feasible owing to decreasing costs in high-throughput sequencing and the recent advances in computation. The unprecedented resolution of whole-genome typing is achieved by genotyping the vari...

Hepatitis C Virus Saint Petersburg Variant Detection With Machine Learning Methods.

Journal of medical virology
Hepatitis C virus infection is a significant global health concern, affecting millions worldwide. Although direct-acting antivirals achieve over 90% success rate, treatment failures still occur, particularly when pan-genotypic DAAs are unavailable, a...