AIMC Topic: Multiomics
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Integrating Multi-Omics Data With EHR for Precision Medicine Using Advanced Artificial Intelligence.
IEEE reviews in biomedical engineering
Jan 12, 2024
With the recent advancement of novel biomedical technologies such as high-throughput sequencing and wearable devices, multi-modal biomedical data ranging from multi-omics molecular data to real-time continuous bio-signals are generated at an unpreced...
Single-cell spatial multi-omics and deep learning dissect enhancer-driven gene regulatory networks in liver zonation.
Nature cell biology
Jan 5, 2024
In the mammalian liver, hepatocytes exhibit diverse metabolic and functional profiles based on their location within the liver lobule. However, it is unclear whether this spatial variation, called zonation, is governed by a well-defined gene regulato...
Mechanism-aware and multimodal AI: beyond model-agnostic interpretation.
Trends in cell biology
Dec 11, 2023
Artificial intelligence (AI) is widely used for exploiting multimodal biomedical data, with increasingly accurate predictions and model-agnostic interpretations, which are however also agnostic to biological mechanisms. Combining metabolic modelling,...
Role of arachidonic acid metabolism in intervertebral disc degeneration: identification of potential biomarkers and therapeutic targets via multi-omics analysis and artificial intelligence strategies.
Lipids in health and disease
Nov 25, 2023
BACKGROUND: Intervertebral disc degeneration (IVDD) is widely recognized as the primary etiological factor underlying low back pain, often necessitating surgical intervention as the sole recourse in severe cases. The metabolic pathway of arachidonic ...
From Microcosm to Macrocosm: The -Omics, Multiomics, and Sportomics Approaches in Exercise and Sports.
Omics : a journal of integrative biology
Nov 9, 2023
This article explores the progressive integration of -omics methods, including genomics, metabolomics, and proteomics, into sports research, highlighting the development of the concept of "sportomics." We discuss how sportomics can be used to compreh...
Prediction of Protein-Protein Interactions Using Vision Transformer and Language Model.
IEEE/ACM transactions on computational biology and bioinformatics
Oct 9, 2023
The knowledge of protein-protein interaction (PPI) helps us to understand proteins' functions, the causes and growth of several diseases, and can aid in designing new drugs. The majority of existing PPI research has relied mainly on sequence-based ap...
Multi-omics integration strategy in the post-mortem interval of forensic science.
Talanta
Sep 29, 2023
Estimates of post-mortem interval (PMI), which often serve as pivotal evidence in forensic contexts, are fundamentally based on assessments of variability among diverse molecular markers (including proteins and metabolites), their correlations, and t...
Ovarian cancer beyond imaging: integration of AI and multiomics biomarkers.
European radiology experimental
Sep 13, 2023
High-grade serous ovarian cancer is the most lethal gynaecological malignancy. Detailed molecular studies have revealed marked intra-patient heterogeneity at the tumour microenvironment level, likely contributing to poor prognosis. Despite large quan...
A deep learning approach based on multi-omics data integration to construct a risk stratification prediction model for skin cutaneous melanoma.
Journal of cancer research and clinical oncology
Sep 7, 2023
PURPOSE: Skin cutaneous melanoma (SKCM) is a highly aggressive melanocytic carcinoma whose high heterogeneity and complex etiology make its prognosis difficult to predict. This study aimed to construct a risk subtype typing model for SKCM.
Graph Neural Networks With Multiple Prior Knowledge for Multi-Omics Data Analysis.
IEEE journal of biomedical and health informatics
Sep 6, 2023
With the development of biotechnology, a large amount of multi-omics data have been collected for precision medicine. There exists multiple graph-based prior biological knowledge about omics data, such as gene-gene interaction networks. Recently, the...
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